Macrophage heterogeneity, phenotypes, and roles in renal fibrosis.
Macrophage heterogeneity, phenotypes, and roles in renal fibrosis.
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DOI：
10.1038/kisup.2014.4
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发表时间：
2014-11
影响因子：
5.5
通讯作者：
Harris DC
中科院分区：
文献类型：
--
作者：
Cao Q;Wang Y;Harris DC
巨噬细胞（MΦ）是高度异质性的细胞，其表现出不同的表型和功能特征，这取决于其微环境和疾病类型和阶段。MΦ分布于正常和病变的肾组织中，在肾组织中它们已被认为是肾纤维化的关键因素。最近的研究已经确定了MΦ在几种小鼠肾脏疾病模型中的表型转换和不同作用。在这篇综述中，我们讨论了巨噬细胞异质性及其参与肾纤维化。
Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis.