A straightforward but not piecewise relationship between age and lymph node status in Chinese breast cancer patients.
A straightforward but not piecewise relationship between age and lymph node status in Chinese breast cancer patients.
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DOI：
10.1371/journal.pone.0011035
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发表时间：
2010-06-09
期刊：
影响因子：
3.7
通讯作者：
Shao ZM
中科院分区：
文献类型：
--
作者：
Yu KD;Li JJ;Di GH;Wu J;Shen ZZ;Shao ZM
探讨年龄与中国乳腺癌患者腋窝淋巴结（LN）受累的关系，并复制最近发现的年龄与淋巴结受累之间的分段关系。数据集来自上海肿瘤医院的数据库，包括3,715例1996年至2006年间连续接受手术治疗的可手术乳腺癌患者（具有研究变量的完整信息）。采用单因素和多因素logistic回归分析年龄与LN的关系。随后，我们对另一个数据集进行了类似的分析，该数据集包括2007年至2008年期间连续治疗的1832名患者，以重复我们在第一个数据集中的发现。年龄和LN状态之间的u型关系（之前在两个欧洲人群中观察到）未能在我们的中国患者数据集中复制。相反，我们观察到的是线性关系，而不是分段关系。多变量调整后，仍存在线性关系。此外，年龄和淋巴结受累之间的相互作用不受肿瘤大小的影响。年龄每增加一年，LN受累率降低1.5% （OR 0.985, 95% CI 0.979-0.991， P<0.001）。乳腺癌亚型也与淋巴结转移有关。基底样和ERBB2+亚型的比例随着年龄的增长而下降。第一个数据集中的观测结果被成功地复制到第二个独立数据集中。我们证实了年龄与中国患者LN状态之间的直接关系，但不是分段关系。在临床决策时应考虑到中国和欧洲老年患者的不同模式。
To investigate the relationship between age and axillary lymph node (LN) involvement in Chinese breast cancer patients, and to replicate a recently identified piecewise relationship between age and LN involvement. A dataset, consisting of 3,715 patients (with complete information on study variables) with operable breast cancer consecutively surgically treated between 1996 and 2006, was derived from the database of Shanghai Cancer Hospital. Univariate and multivariate logistic regression were employed to analyze the relationship between age and LN. We subsequently performed a similar analysis on another dataset including 1,832 consecutive patients treated between 2007 and 2008 to replicate our findings in the first dataset. A U-shaped relationship (previously observed in two European populations) between age and LN status failed to be replicated in our dataset of Chinese patients. Instead, we observed a linear rather than piecewise relationship. After multivariate adjustment, the linear relationship was still present. Moreover, the interaction between age and LN involvement was not modified by tumor size. The odds of LN involvement decreased by 1.5% for each year increase in age (OR 0.985, 95% CI 0.979–0.991, P<0.001). Breast cancer subtypes were also associated with LN status. Proportions of basal-like and ERBB2+ subtypes decreased with increasing age. The observations in the first dataset were successfully replicated in a second independent dataset. We confirmed a straightforward but not piecewise relationship between age and LN status in Chinese patients. The different pattern between Chinese and European elderly patients should be considered when making clinical decisions.
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DOI：
10.1088/1475-7516/2005/01/007
发表时间：
2005-01-01
影响因子：
6.4
作者：
Martin, J;Ringeval, C
通讯作者：
Ringeval, C
影响因子：
6.4
作者：
Bertucci, Francois;Finetti, Pascal;Birnbaum, Daniel
通讯作者：
Birnbaum, Daniel
影响因子：
3.9
作者：
Yu, Ke-Da;Liu, Guang-Yu;Shao, Zhi-Ming
通讯作者：
Shao, Zhi-Ming
影响因子：
4.6
作者：
Lee, Jong Hoon;Kim, Sung Hwan;Kim, Hoon Kyo
通讯作者：
Kim, Hoon Kyo
影响因子：
4
作者：
Takei, Hiroyuki;Kurosumi, Masafumi;Tabei, Toshio
通讯作者：
Tabei, Toshio