BRAIN CT CHANGES IN ALCOHOLICS - EFFECTS OF AGE AND ALCOHOL-CONSUMPTION
BRAIN CT CHANGES IN ALCOHOLICS - EFFECTS OF AGE AND ALCOHOL-CONSUMPTION
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DOI：
10.1111/j.1530-0277.1988.tb00137.x
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发表时间：
1988-02-01
期刊：
影响因子：
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通讯作者：
JERNIGAN, TL
中科院分区：
文献类型：
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作者：
PFEFFERBAUM, A;ROSENBLOOM, M;JERNIGAN, TL
研究人员对 37 名年龄在 26-62 岁的男性酗酒者进行了计算机断层扫描 (CT) 脑部扫描，并对终生饮酒量、体型和认知能力进行了评估。还测量了血细胞比容和平均红细胞体积（MCV）。使用半自动评分系统分析 CT 数据，测量心室和皮质沟的液体百分比。来自 57 个社区对照的成年年龄范围的规范脑部 CT 数据允许对每个酗酒者与年龄标准的偏差进行 Z 评分评估。在整个群体中，酗酒者的心室和脑沟明显扩大（与同龄人相比）。两个部位的增大都与终生饮酒量显着相关。所有年龄段的酗酒者都发现脑沟扩大。相比之下，心室扩大仅在老年酗酒者中才明显，并且随着年龄的增长而变得越来越夸张。身体大小、血细胞比容和 MCV 的测量与心室扩大相关，但与脑沟扩大无关，表明营养因素在心室扩大中发挥作用。神经心理学表现与 CT 变化或饮酒之间的关联不太明显，有时甚至违反直觉。研究结果支持乙醇暴露与大脑形态变化之间存在适度的剂量效应关系，并表明脑室和脑沟表现出不同的反应时间过程。需要更仔细地研究营养状况的作用。
A computerized tomographic (CT) brain scan and assessments of lifetime alcohol consumption, body size, and cognitive performance were performed in 37 male alcoholics, aged 26-62 years. Hematocrit and mean corpuscular volume (MCV) were also measured. CT data were analyzed using a semiautomated scoring system yielding measures of percentage of fluid at the ventricles and cortical sulci. Normative brain CT data from 57 community controls spanning the adult age range allowed Z-score assessment of deviation from age norms for each alcoholic. Across the entire group, alcoholics had significantly enlarged ventricles and sulci for their age. Enlargement at both sites correlated significantly with lifetime alcohol consumption. Sulcal enlargement in alcoholics was found across all ages. In contrast, ventricular enlargement was apparent only in older alcoholics and became increasingly exaggerated with age. Measures of body size, hematocrit, and MCV correlated with ventricular but not sulcal enlargement, suggesting that nutritional factors play a role in ventricular enlargement. Associations between neuropsychological performance and CT changes or alcohol consumption were less pronounced and at times counterintuitive. The findings support a modest dose-effect relationship between ethanol exposure and changes in brain morphology, and suggest that ventricles and sulci show a different time course of response. The role of nutritional status needs to be more closely investigated.