Biomimetic coatings on titanium:: a crystal growth study of octacalcium phosphate
Biomimetic coatings on titanium:: a crystal growth study of octacalcium phosphate
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DOI：
10.1023/a:1011271713758
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发表时间：
2001-01-01
影响因子：
3.7
通讯作者：
de Groot, K
中科院分区：
文献类型：
--
作者：
Barrère, F;Layrolle, P;de Groot, K
仿生方法允许用不同的磷酸钙（Ca-P）相涂覆金属植入物。在生理条件下制备的薄膜显示出与骨矿物质非常相似的结构。例如，磷酸八钙（OCP，Ca-8（HPO 4）（2）（PO 4）（4）。5 H（2）O）晶体沉积在钛表面。清洁和蚀刻后，将Ti6 Al 4V板浸入模拟体液（SBF 1）中24 h。在金属基体上沉积了一层薄的无定形碳酸化Ca-P层。其次，将这些薄的Ca-P涂覆的钛基材浸入另一种模拟体液（SBF 2）中48 h。薄的无定形碳酸化Ca-P层诱导由OCP晶体组成的厚度为55 μ m的第二Ca-P层的快速沉淀。在SBF 2中浸泡时间对Ca和P浓度的测量表明，在OCP涂层沉积之前，碳酸化的Ca-P层部分溶解。X射线衍射（XRD）表明，OCP晶体在衬底上外延生长。OCP是骨矿化过程中的前体物质之一，因此，这种新一代的仿生涂层在骨科手术中具有良好的应用前景。(C)2001 Kluwer Academic Publishers.
The biomimetic approach allows the coating of metal implants with different calcium-phosphate (Ca-P) phases. Films elaborated at physiological conditions exhibited structures closely resembling those of bone mineral. For instance, octacalcium phosphate (OCP, Ca-8(HPO4)(2)(PO4)(4). 5H(2)O) crystals have been deposited on titanium through a two-step procedure. After cleaning and etching, Ti6Al4V plates were immersed for 24 h into a simulated body fluid (SBF1). A thin amorphous carbonated Ca-P layer precipitated on the metal substrate. Secondly, these thinly Ca-P coated titanium substrates were immersed for 48 h into another simulated body fluid (SBF2). The thin amorphous carbonated Ca-P layer induced the fast precipitation of a second Ca-P layer of 55 mum in thickness composed of OCP crystals. The measurements of Ca and P concentrations versus soaking time in SBF2 showed that the carbonated Ca-P layer partially dissolved before the deposition of the OCP coating. X-ray diffraction (XRD) revealed that OCP crystals grew epitaxially on the substrate. OCP is known to be one of the precursors during the bone mineralization process, thereby, this new generation of biomimetic coatings are promising for orthopedic surgery. (C) 2001 Kluwer Academic Publishers.