Altered relationship between electrophysiological response to errors and gray matter volumes in an extended network for error-processing in pediatric obsessive-compulsive disorder.
Altered relationship between electrophysiological response to errors and gray matter volumes in an extended network for error-processing in pediatric obsessive-compulsive disorder.
复制标题
改变了儿科强迫症错误处理扩展网络中对错误的电生理反应与灰质体积之间的关系。
DOI：
10.1002/hbm.22240
复制
发表时间：
2014
影响因子：
4.8
通讯作者：
Fitzgerald,KateD
中科院分区：
文献类型：
--
作者：
Liu,Yanni;Hanna,GregoryL;Carrasco,Melisa;Gehring,WilliamJ;Fitzgerald,KateD
患有强迫症（OCD）的儿童患者对错误的电生理反应增加，这被认为是局限于后内侧前额叶皮层（pMFC）。然而，这种反应，即误差相关的负性（ERN），与潜在的大脑结构之间的关系尚不清楚。在对20名儿童强迫症患者和20名健康青年的检查中，我们发现负ERN幅值越大，前额皮质和眶额皮质灰质（GM）密度越低。ERN与pMFC灰质体积的关联由患者组驱动。此外，观察到ERN与右脑岛灰质关联的组间差异，显示这些指标在健康青年中存在关联（更负的ERN振幅与更低的脑岛GM密度相关），但在患者中没有。这些发现提供了初步证据，证明错误处理扩展网络中的灰质体积与ERN有关，并表明该网络的结构改变可能是儿童强迫症中ERN夸大的基础。中国生物医学工程学报（英文版），2014。©2013 Wiley期刊公司
Pediatric patients with obsessive‐compulsive disorder (OCD) show an increased electrophysiological response to errors that is thought to be localized to the posterior medial prefrontal cortex (pMFC). However, the relation of this response, the error‐related negativity (ERN), to underlying brain structures remains unknown. In an examination of 20 pediatric OCD patients and 20 healthy youth, we found that more negative ERN amplitude was correlated with lower gray matter (GM) density in pMFC and orbital frontal cortex. The association of the ERN with pMFC gray matter volume was driven by the patient group. In addition, a group difference in the association of ERN with gray matter in right insula was observed, showing an association of these measures in healthy youth (more negative ERN amplitude was associated with lower GM density in insula), but not in patients. These findings provide preliminary evidence linking gray matter volumes in an extended network for error processing to the ERN, and suggest that structural alterations in this network may underlie exaggeration of the ERN in pediatric OCD.Hum Brain Mapp 35:1143–1153, 2014. © 2013 Wiley Periodicals, Inc.