Antibody responses to SARS-CoV-2 in patients with COVID-19
Antibody responses to SARS-CoV-2 in patients with COVID-19
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DOI：
10.1038/s41591-020-0897-1
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发表时间：
2020-04-29
期刊：
影响因子：
82.9
通讯作者：
Huang, Ai-Long
中科院分区：
文献类型：
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作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
我们报告了285例COVID-19患者中对SARS-COV-2的急性抗体反应。症状发作后的19天内，100％的患者在抗病毒免疫球蛋白G（IgG）中测试阳性。 IgG和IgM的血清转换同时或顺序发生。血清转化后6天内，IgG和IgM滴度都在平稳。血清学检测可能有助于诊断可疑的RT-PCR结果阴性患者并鉴定无症状感染。表明SARS-COV2特异性IgG或IgM血清转化发生在症状发作后20天内。
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.