Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain
Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain
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DOI：
10.1023/a:1008867108960
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发表时间：
1999-02-01
影响因子：
2.3
通讯作者：
Riboli, E
中科院分区：
文献类型：
--
作者：
Garcia-Closas, R;Gonzalez, CA;Riboli, E
目的：利用食物中特定类胡萝卜素(α-胡萝卜素、β-胡萝卜素、叶黄素和番茄红素)和类黄酮类(栎素、山奈酚、杨梅素和木犀草素)摄入量的最新数据，探讨其与胃癌的关系。方法：在西班牙进行病例对照研究，354例胃癌患者和354名对照按年龄、性别、居住地和医院相匹配。结果：在调整了几种饮食因素的多变量模型中，没有发现研究中的任何一种类胡萝卜素的摄入量与胃癌风险之间的关联。总黄酮类摄入量最高四分位数与最低四分位数对胃癌的调整OR为0.003.44(95%可信区间[CI]=0.2 5~0.78；趋势P=0.0 5)。山奈酚摄入量是保护性的(OR=0.48；CI=0.26-0.88，趋势=0.04)，比较摄入量最高和最低四分位数。结论：这项研究的结果支持了这样的假设，即水果和蔬菜对胃癌的保护作用已经得到证实，部分原因可能是由于类黄酮的存在。
Objectives: To investigate the relationship between gastric cancer and the intake of specific carotenoids (alpha-carotene, beta-carotene, lutein, and lycopene) and flavonoids (quercetin, kaempferol, myricetin, and luteolin) using new data on their concentration in foods.Methods: Case-control study carried out in Spain that included 354 cases of gastric cancer and 354 controls, matched by age, gender, area of residence and hospital. Usual food intake was assessed using a dietary history questionnaire.Results: In a multivariate model adjusted for several dietary factors, no association was found between intake of any of the studied carotenoids and the risk of gastric cancer. The adjusted OR of gastric cancer for the highest quartile of total flavonoid intake versus the lowest quartile was 0.44 (95 percent confidence interval [CI] = 0.25-0.78; P for trend = 0.003). Kaempferol intake was found to be protective (OR = 0.48; CI = 0.26-0.88, P for trend = 0.04) comparing the highest versus the lowest quartile of intake. A trend toward lower risk of stomach cancer with higher intake of quercetin was also found.Concusions: The results of this study support the hypothesis that the well-established protective effect of fruit and vegetables against gastric cancer could, in part, be due to the presence of flavonoids.