EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.
EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.
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DOI：
10.1517/14728222.2011.541440
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发表时间：
2011-01
影响因子：
5.8
通讯作者：
Van Waes C
中科院分区：
文献类型：
--
作者：
Freudlsperger C;Burnett JR;Friedman JA;Kannabiran VR;Chen Z;Van Waes C
在了解头颈部鳞状细胞癌（HNSCC）的肿瘤发生的最新进展揭示了多种失调的信号通路。一个经常改变的轴是EGFR/PI 3 K/Akt/mTOR通路。该途径在许多细胞过程中起核心作用，包括代谢、细胞生长、凋亡、存活和分化，其最终促成HNSCC进展。本文综述了EGFR/PI 3 K/Akt/mTOR信号在HNSCC中的作用，包括遗传和表观遗传改变的影响。这篇综述进一步强调了靶向这一信号级联反应作为治疗HNSCC的一种有前途的治疗方法的潜力。对书籍、期刊、数据库和网站进行了检索，以提供关于该主题的最新综述。该途径中几个节点的遗传改变，包括遗传和表观遗传变化，导致癌基因激活或肿瘤抑制因子失活，经常与HNSCC有关。因此，靶向该途径的中心节点的药物对于分子导向的癌症治疗已经变得有吸引力。许多临床前和临床研究正在HNSCC中进行，然而，仍然需要更多的研究来更好地了解这一途径的生物学。
Recent advances in understanding the oncogenesis of head and neck squamous cell carcinomas (HNSCC) have revealed multiple dysregulated signaling pathways. One frequently altered axis is the EGFR/PI3K/Akt/mTOR pathway. This pathway plays a central role in numerous cellular processes including metabolism, cell growth, apoptosis, survival and differentiation, which ultimately contributes to HNSCC progression. This article reviews the current understanding of EGFR/PI3K/Akt/mTOR signaling in HNSCC, including the impact of both genetic and epigenetic alterations. This review further highlights the potential of targeting this signaling cascade as a promising therapeutic approach in the treatment of HNSCC. Books, journals, databases and websites have been searched to provide a current review on the subject. Genetic alterations of several nodes within this pathway, including both genetic and epigenetic changes, leading to either oncogene activation or inactivation of tumor suppressors, have frequently been implicated in HNSCC. Consequently, drugs that target the central nodes of this pathway have become attractive for molecular oriented cancer therapies. Numerous preclinical and clinical studies are being performed in HNSCC, however, more studies are still needed to better understand the biology of this pathway.
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