Computational Methods for Continuum Models of Platelet Aggregation
Computational Methods for Continuum Models of Platelet Aggregation
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DOI：
10.1006/jcph.1999.6212
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发表时间：
1999-05
影响因子：
4.1
通讯作者：
Nien-Tzu Wang;A. Fogelson
中科院分区：
文献类型：
--
作者：
Nien-Tzu Wang;A. Fogelson
血小板聚集在血液凝固过程中起着重要作用。已经开发了模拟血小板聚集的Fogelson连续统模型行为的鲁棒数值方法，特别是涉及模型链演化方程的混合有限差分和谱方法。这个偏微分方程涉及四个空间维度和时间。新方法用于开始研究新的化学诱导活化、链接形成和剪切诱导链接断裂对确定聚集体何时形成足够的强度以保持完整以及何时被流体应力破坏的影响。
Platelet aggregation plays an important role in blood clotting. Robust numerical methods for simulating the behavior of Fogelson's continuum models of platelet aggregation have been developed which in particular involve a hybrid finite-difference and spectral method for the models' link evolution equation. This partial differential equation involvesfourspatial dimensions and time. The new methods are used to begin investigating the influence of new chemically induced activation, link formation, and shear-induced link breaking in determining when aggregates develop sufficient strength to remain intact and when they are broken apart by fluid stresses.