Arterial pulse wave velocity and cognition with advancing age.
Arterial pulse wave velocity and cognition with advancing age.
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DOI：
10.1161/hypertensionaha.108.126342
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Elias PK
中科院分区：
文献类型：
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作者：
Elias MF;Robbins MA;Budge MM;Abhayaratna WP;Dore GA;Elias PK
我们假设颈动脉-股动脉脉搏波速度（动脉硬度的标志物）与年龄相互作用，使得脉搏波速度与认知能力之间的关联程度随着年龄的增加而增加，并且尽管对人口统计学变量、平均动脉压和心血管危险因素进行了调整，仍观察到这种相互作用。在缅因州-锡拉丘兹纵向研究的409名无痴呆和中风的参与者（24至92岁，62.3%为女性）中，使用压平眼压测量法估计脉搏波速度。在横断面设计中使用线性回归分析，检查脉搏波速度、年龄以及脉搏波速度与年龄的相互作用与总体综合评分、韦氏成人智力量表相似性测试（抽象推理）和由多种认知测量指标索引的四个认知领域之间的关联。调整年龄、性别、教育程度、身高、体重、心率、平均动脉压和抗高血压治疗，通过年龄相互作用获得脉搏波速度，用于整体、视觉空间组织和记忆、扫描和跟踪以及言语情景记忆复合和相似性。较高的脉搏波速度和年龄的结合导致认知能力逐渐降低。这一发现与扩展模型相同，扩展模型还包括对心血管危险因素和其他混淆因素的调整。脉搏波传导速度与年龄呈倍数交互作用，对认知能力水平产生负面影响。早期干预，以防止动脉僵硬度的增加可能会发挥重要作用，在保护认知能力。
We hypothesized that carotid-femoral pulse wave velocity, a marker of arterial stiffness, interacts with age such that the magnitude of associations between pulse wave velocity and cognitive performance are greater with increasing age, and that this interaction is observed despite adjustments for demographic variables, mean arterial pressure, and cardiovascular risk factors. Pulse wave velocity was estimated using applanation tonometry in 409 dementia- and stroke-free participants of the Maine-Syracuse Longitudinal Study (24 to 92 years of age, 62.3% women). Using linear regression analyses in a cross-sectional design, associations between pulse wave velocity, age, and the interaction of pulse wave velocity and age were examined in relation to a Global composite score, the Wechsler Adult Intelligence Scale Similarities test (abstract reasoning) and four cognitive domains indexed by multiple cognitive measures. Adjusting for age, gender, education, height, weight, heart rate, mean arterial pressure, and antihypertensive treatment, pulse wave velocity by age interactions were obtained for the Global, Visual-Spatial Organization and Memory, Scanning and Tracking, and Verbal Episodic Memory composites, and Similarities. The combination of higher pulse wave velocity and age resulted in progressively lower cognitive performance. This finding was the same with an extended model which also included adjustment for cardiovascular risk factors and other confounds. Pulse wave velocity interacts with age in a multiplicative way to exert a negative influence on cognitive performance level. Early interventions to prevent an increase in arterial stiffness could possibly play an important role in preservation of cognitive ability.