A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy
A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy
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DOI：
10.1016/j.canlet.2009.08.010
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发表时间：
2010-03-28
期刊：
影响因子：
9.7
通讯作者：
Le, Anh D.
中科院分区：
文献类型：
--
作者：
Zhang, Qunzhou;Shi, Shihong;Le, Anh D.
研究人员检查了癌症干细胞样细胞（CSC）在人类口腔鳞状细胞癌（OSCC）化疗耐药中的潜在作用。在 OSCC 细胞系和组织中鉴定出一小部分 CD133(+) CSC 亚群 (1-2%)。与 CD133(-) 对应物相比，这些 CD133(+) CSC 具有更高的克隆形成性、侵袭性和更高的体内致瘤性。同时，CD133(+) CSCs对标准化疗具有显着抵抗性，其中紫杉醇的体外和体内治疗均导致CD133(+) CSCs显着富集。我们的数据表明，CD133(+)细胞代表了一小部分CSC，可能导致人类OSCC的化疗耐药。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133(+) CSCs was identified in OSCC cell lines and tissues. These CD133(+) CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133(-) counterparts. Meanwhile, CD133(+) CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133(+) CSCs. Our data suggest that CD133(+) cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.