Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia
Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia
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DOI：
10.1177/117727190600100012
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发表时间：
2006-01
影响因子：
3.8
通讯作者：
O. Matsuno;E. Miyazaki;S. Nureki;T. Ueno;M. Ando;T. Kumamoto
中科院分区：
文献类型：
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作者：
O. Matsuno;E. Miyazaki;S. Nureki;T. Ueno;M. Ando;T. Kumamoto
背景CD26是一种多功能的T细胞表面糖蛋白，是一种II型跨膜蛋白，在其胞浆区仅含有6个氨基酸残基。除了其膜形式外，CD26还以可溶形式（sCD26）存在于血浆中，其被认为是从细胞表面裂解的分子的胞外结构域。近年来的研究表明，CD26在哮喘的发病机制中起重要作用，称为Th2样疾病。CD26在嗜酸性粒细胞性肺病中的作用尚不清楚。方法采用酶联免疫吸附试验（ELISA）检测急性嗜酸粒细胞性肺炎（EP）、慢性嗜酸粒细胞性肺炎（CEP）、结节病患者及健康志愿者血清sCD 26水平，探讨sCD 26对疾病的鉴别诊断价值及作为疾病活动性指标的意义。结果CEP患者血清可溶性CD26水平明显降低，且与疾病严重程度相关。特别是，sCD 26与CEP中的动脉氧分压呈负相关。结论血清sCD 26水平可作为CEP疾病活动性的一个新指标。
Backgrounds CD26, a multifunctional T cell surface glycoprotein, is a type II transmembrane protein containing only six amino acid residues in its cytoplasmic region. In addition to its membrane form, CD26 exists in plasma in a soluble form (sCD26), which is thought to be the extracellular domain of the molecule cleaved from the cell surface. Recent studies indicated CD26 have an important role in the pathogenesis of asthma, known as Th2 like disease. The function of CD26 in the esosinophlic lung disease is not well understood. Methods Serum sCD26 was determined by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia, chronic eosinophilic pneumonia (CEP), and sarcoidosis, and in healthy volunteers, to establish its value for discriminating between disease entities and as marker of disease activity. Results Soluble CD26 was significantly reduced in CEP and was related to disease severity. In particular, sCD26 was inversely correlated with arterial oxygen tension in CEP. Conclusion Serum levels of sCD26 might appear to be useful as a new marker of CEP disease activity.