DIRECTED GENETIC CHANGE MODEL FOR X CHROMOSOME INACTIVATION IN EUTHERIAN MAMMALS
DIRECTED GENETIC CHANGE MODEL FOR X CHROMOSOME INACTIVATION IN EUTHERIAN MAMMALS
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DOI：
10.1038/230292a0
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发表时间：
1971-01-01
期刊：
影响因子：
64.8
通讯作者：
COOPER, DW
中科院分区：
文献类型：
--
作者：
COOPER, DW
该模型假设，在真兽目的随机X失活已经从祖先的父系X失活，已保留在有袋类动物。它提出，在两组的雄性减数分裂期间，X染色体都经历了定向遗传变化。一个控制元素被引入X，可能是通过Y。然后，在真兽目哺乳动物发育早期的某个时刻，这个控制元件被切除，随后随机重新插入2条X染色体中的一条，从而建立随机的X失活。一旦重新插入，它就保持固定在该染色体上。检查了该模型解释目前可用数据的充分性，并建议了可能的实验测试。
The model postulates that random X inactivation in eutherians has evolved from an ancestral paternal X inactivation which has been retained in marsupials. It proposes that during ♂ meiosis in both groups the X-chromosome undergoes a directed genetic change. A controlling element is introduced into the X, probably by the Y. Then, at a certain point in the very early development of eutherian ♀♀, this controlling element is excised and later re-inserted at random into one of the 2 X-chromosomes, thus setting up random X inactivation. Once re-inserted, it remains fixed in that chromosome. The adequacy with which this model accounts for data at present available is examined, and possible experimental tests are suggested.