Application of electrolysis for detoxification of an antineoplastic in urine.
Application of electrolysis for detoxification of an antineoplastic in urine.
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DOI：
10.1016/j.ecoenv.2011.11.028
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发表时间：
2012-04
影响因子：
6.8
通讯作者：
Toyohide Kobayashi;J. Hirose;K. Sano;R. Kato;Y. Ijiri;H. Takiuchi;Kazuhiko Tanaka;Emi Goto;H. Tamai;T. Nakano
中科院分区：
文献类型：
--
作者：
Toyohide Kobayashi;J. Hirose;K. Sano;R. Kato;Y. Ijiri;H. Takiuchi;Kazuhiko Tanaka;Emi Goto;H. Tamai;T. Nakano
患者排泄物中的抗菌塑料被认为是地表水中细胞毒性、致癌、致畸和致突变污染物的来源之一。最近的研究表明，医疗废水中的抗菌塑料可以通过电解来解毒。在这项研究中，开发一种方法，用于解毒的粪便中的抗虫塑料，甲氨蝶呤溶液在人尿的存在下进行电解和评价。我们发现，尿液抑制电解解毒，然而，这种抑制减少稀释尿液。尿样中0.9%NaCl溶液阳极氧化灭活抗菌塑料产生的活性氯浓度呈稀释依赖性和时间依赖性增加。这些结果表明，铂基氧化铱复合电极电解是一种可能的方法，对尿液中的某种毒素进行解毒。
Antineoplastics in excreta from patients have been considered to be one of the origins of cytotoxic, carcinogenic, teratogenic, and mutagenic contaminants in surface water. Recent studies have demonstrated that antineoplastics in clinical wastewater can be detoxified by electrolysis. In this study, to develop a method for the detoxification of antineoplastics in excreta, methotrexate solution in the presence of human urine was electrolyzed and evaluated. We found that urine inhibits detoxification by electrolysis; however, this inhibition decreased by diluting urine. In urine samples, the concentrations of active chlorine generated by anodic oxidation from 0.9% NaCl solution for inactivation of antineoplastics increased in dilution-dependent and time-dependent manner. These results indicate that electrolysis with platinum-based iridium oxide composite electrode is a possible method for the detoxification of a certain antineoplastic in urine.