Goto-kakizaki Rats: Its Suitability as Non-obese Diabetic Animal Model for Spontaneous Type 2 Diabetes Mellitus
Goto-kakizaki Rats: Its Suitability as Non-obese Diabetic Animal Model for Spontaneous Type 2 Diabetes Mellitus
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DOI：
10.2174/15733998113099990069
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发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Chen, Shuqing
中科院分区：
文献类型：
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作者：
Akash, Muhammad Sajid Hamid;Rehman, Kanwal;Chen, Shuqing
β-细胞功能障碍和细胞凋亡被认为是响应高血糖和代谢需求的胰岛素分泌不足的主要原因。因此，已知会发生2型糖尿病（T2 DM）。考虑到T2 DM的病因，直接对人类糖尿病患者进行调查研究似乎不合适;因此，已经建立了各种动物模型来研究T2 DM的发病机制。在这些模型中，Goto-Kakizaki（GK）大鼠被认为是最好的非肥胖2型糖尿病动物模型之一。GK大鼠表现出有价值的特征工具，或多或少常见，并在人类糖尿病患者中发挥作用。认为该动物模型适合于检查T2 DM的各种病理机制。因此，在我们目前的文章中，我们已经全面总结了有关的信息异常的特点，包括在GK大鼠的发病机制参与的各种机制的描述。这可能有助于研究自发性T2 DM的各个方面。
beta-cell dysfunction and apoptosis are recognized as a major cause of insufficient insulin secretion in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. Taking into account the etiology of T2DM, to conduct investigational studies directly on human diabetic patients seems to be unsuitable; thereby, various animal models have been established to investigate the pathogenesis of T2DM. Among these models, Goto-Kakizaki (GK) rats have been considered as one of the best non-obese type 2 diabetic animal model. GK rats exhibit valuable characteristic tools that are more or less common and functionally present in human diabetic patients. This animal model is considered appropriate to inspect various pathologic mechanisms of T2DM. Thereby, in our present article, we have comprehensively summarized the information relating the characteristics of abnormalities including a description of assorted mechanisms involved in pathogenesis of T2DM in GK rats. This might help to investigate various aspects of spontaneous T2DM.