Heparin‐induced Extracorporeal Low‐density Lipoprotein Precipitation
Heparin‐induced Extracorporeal Low‐density Lipoprotein Precipitation
复制标题
肝素诱导体外低密度脂蛋白沉淀
DOI：
--
复制
发表时间：
2003
影响因子：
1.9
通讯作者：
K. Mellwig
中科院分区：
文献类型：
--
作者：
K. Mellwig
翻译后摘要：肝素诱导的体外低密度脂蛋白（LDL）沉淀（HELP）是一种选择性和仔细的单采程序。通过应用肝素和降低pH值，脂蛋白和纤维蛋白原减少了50- 60%。此外，在动脉粥样硬化的发展和进展中起关键作用的粘附分子（ICAM-1，VCAM-1，p-选择素）也明显减少。在LDL单采术后20小时进行的PET扫描显示冠状血管舒张能力的改善。这主要是由于LDL胆固醇和纤维蛋白原的显著降低以及内皮功能障碍和流变学的连续改善。
Abstract: Heparin‐induced extracorporeal low‐density lipoprotein (LDL) precipitation (HELP) is a selective and careful apheresis procedure. Through the application of heparin and lowering the pH value, lipoproteins and fibrinogen are reduced by 50–60%. In addition, adhesion molecules (ICAM‐1, VCAM‐1, p‐selectin) which play a key role in the development and progression of atherosclerosis, are also markedly reduced. A PET scan performed 20 h after LDL apheresis shows the improvement of coronary vasodilation capacity. This is supposed to be mainly due to the marked reduction of LDL cholesterol and fibrinogen with consecutive improvement of endothelial dysfunction and rheology.