Intrauterine Growth Restriction in Twin Pregnancies: Incidence and Associated Risk Factors
Intrauterine Growth Restriction in Twin Pregnancies: Incidence and Associated Risk Factors
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DOI：
10.1055/s-0030-1270116
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发表时间：
2011-04-01
影响因子：
2
通讯作者：
Saltzman, Daniel H.
中科院分区：
文献类型：
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作者：
Fox, Nathan S.;Rebarber, Andrei;Saltzman, Daniel H.
我们试图评估一些母体危险因素与双胎宫内生长受限（IUGR）的关系。这是一项病例对照研究，纳入了2005年6月至2010年1月期间分娩超过24周的313例双胎妊娠患者。我们使用了IUGR的三种定义：（1）双胞胎中的任何一个出生体重<胎龄第10百分位数;（2）双胞胎中的任何一个出生体重<胎龄第5百分位数;（3）出生体重不一致≥ 20%。使用IUGR的每种定义，我们估计IUGR与母亲年龄、体重、单绒毛膜、体外受精、妊娠减少、血栓形成倾向、高血压和糖尿病之间的关系。总体而言，47%的患者至少有一对双胞胎的出生体重<第10百分位数，27%的患者至少有一对双胞胎的出生体重<第5百分位数，16%的患者出生体重不一致>= 20%。在双胎妊娠中使用这三种定义中的任何一种，IUGR和任何检查的危险因素之间都没有显著的关联。当我们排除所有分娩的患者时，
We sought to estimate the association of several maternal risk factors with intrauterine growth restriction (IUGR) in twin pregnancies. This is a case-control study of 313 patients with twin pregnancies delivered greater than 24 weeks between June 2005 and January 2010. We used three definitions of IUGR: (1) either twin with a birth weight < 10th percentile for gestational age; (2) either twin with a birth weight < 5th percentile for gestational age; and (3) birth-weight discordance >= 20%. Using each definition of IUGR, we estimated the association between IUGR and maternal age, weight, monochorionicity, in vitro fertilization, pregnancy reduction, thrombophilia, hypertension, and diabetes. Overall, 47% of patients delivered at least one twin with a birth weight < 10th percentile, 27% of patients delivered at least one twin with a birth weight < 5th percentile, and 16% of patients had birth-weight discordance of >= 20%. Using any of these three definitions for IUGR in twin pregnancies, there was no significant association between IUGR and any of the risk factors examined. This remained true when we excluded all patients who delivered