Retrograde transport of nerve growth factor from olfactory bulb to olfactory epithelium
Retrograde transport of nerve growth factor from olfactory bulb to olfactory epithelium
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DOI：
10.1097/00001756-199801050-00031
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发表时间：
1998-01-05
期刊：
影响因子：
1.7
通讯作者：
Morjizumi, T
中科院分区：
文献类型：
--
作者：
Miwa, T;Uramoto, N;Morjizumi, T
神经生长因子产生于嗅球，并从嗅球转运至斜角带水平支的胆碱能神经元。尽管已有研究报道嗅上皮细胞中存在NGF受体的表达，但未见NGF与嗅上皮细胞之间的相关性，本研究旨在通过放射发光法研究嗅觉神经系统中是否存在NGF的逆行转运。I-125标记的神经生长因子注入嗅球，并采取了运输到嗅上皮18小时后注射。这一发现表明，球神经生长因子可能作为嗅上皮细胞的神经营养因子。
NGF is produced in the olfactory bulb and transported from the bulb to cholinergic neurons in the horizontal limb of the diagonal band. Although the expression of NGF receptors has been reported in olfactory epithelial cells, no correlation between NGF and olfactory epithelial cells has been found. This study aimed to define whether or not retrograde transport of NGF occurs in the olfactory neural system using the method of radioluminography. I-125-labeled NGF injected into the olfactory bulb was taken up and transported to the olfactory epithelium 18 h after injection. This finding suggests that bulbar NGF may act as a neurotrophic factor in olfactory epithelial cells.