Sex differences in memory performance in the object recognition test. Possible role of histamine receptors
Sex differences in memory performance in the object recognition test. Possible role of histamine receptors
复制标题
DOI：
10.1016/s0091-3057(99)00143-4
复制
发表时间：
1999-12-01
影响因子：
3.6
通讯作者：
Ferretti, C
中科院分区：
文献类型：
--
作者：
Ghi, P;Orsetti, M;Ferretti, C
在物体再认实验中比较了雌雄大鼠的记忆表现。女性仍然能够识别一个先前确定的对象后，90分钟的试验间隔，相比之下，只有60分钟的男性。由于组胺（HA）参与记忆过程已被强烈建议，H3-HA自身受体拮抗剂硫代哌丁胺的影响进行了研究。发现这种药物在两种性别中都产生剂量依赖性的记忆促进作用，但它不影响记忆恢复的时间过程。将这些行为数据与皮质膜中H1-HA、H2-HA和H3-HA受体的密度进行比较。H1-HA和H2-HA受体的密度在雌性中较大，而H3-HA的密度在两性中基本相同。硫代哌丁胺的行为效应在两种性别中非常相似，这与相似的H3-HA受体密度一致;然而，在硫代哌丁胺治疗后，雌性动物的记忆力表现可能会更好（考虑到不同的H1-HA和H2-HA受体密度），但是没有发现这一点。研究了其在调节胆碱能记忆效应中的可能作用。东莨菪碱减少视觉检索拮抗硫哌丁胺在两种性别中以类似的方式。总之，这些数据表明，女性在视觉记忆测试中表现更好，但这种行为差异不会受到MS-HA受体依赖性操纵组胺能和胆碱能系统的影响。(C)1999 Elsevier Science Inc.
The mnemonic performances of male and female rats were compared in an object recognition test. Females were still able to recognize a previously identified object after a 90-min between-trial interval, compared with only 60 min in the males. Because histamine (HA) involvement in memory processes has been strongly suggested, the effect of H3-HA autoreceptor antagonist thioperamide was investigated. This drug was found to produce a dose-dependent promnestic effect in both sexes, but it did not influence the time course of memory retrieval. These behavioral data were compared to the density of H1-HA, H2-HA, and H3-HA receptors in cortical membranes. The densities of H1-HA and H2-HA receptors were greater in the females, whereas that of H3-HA was substantially the same in both sexes. The behavioral effect of thioperamide was very similar in both sexes, and this agrees with a similar H3-HA receptor density; however a better memory performance might have been expected in the female after thioperamide treatment (in view of different H1-HA and H2-HA receptor density), but this was not found. Because thioperamide has also been demonstrated to influence the acetylcholine release, its possible role in regulating the cholinergic memory effect was investigated. The scopolamine-reduced visual retrieval was antagonized by thioperamide in a similar way in both sexes. In conclusion, these data have shown a better performance of the female in a visual memory test, but this behavioral difference could not be affected by an MS-HA receptor-dependent manipulation of histaminergic and cholinergic systems. (C) 1999 Elsevier Science Inc.