SENSORIMOTOR AND COGNITIVE CONSEQUENCES OF MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS
SENSORIMOTOR AND COGNITIVE CONSEQUENCES OF MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS
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DOI：
10.1016/0006-8993(92)90085-n
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发表时间：
1992-03-20
期刊：
影响因子：
2.9
通讯作者：
SCHNEIDERMAN, N
中科院分区：
文献类型：
--
作者：
MARKGRAF, CG;GREEN, EJ;SCHNEIDERMAN, N
将大鼠进行右侧近端大脑中动脉（MCA）闭塞或假手术，并在一系列旨在测量简单运动功能、感觉运动整合和认知功能的测试中进行长时间的检查。 大脑中动脉闭塞的大鼠表现出广泛的背外侧纹状体神经元的损失和顶叶，颞叶和额外侧新皮质的可变神经元损失。 大脑中动脉闭塞的动物在姿势反射，视觉和触觉前肢放置，运动协调和测试的同时双边触觉灭绝的测试中表现出显着的障碍。 缺血后第30天，反射和感觉运动功能缺陷恢复至术前水平。 手术后5周，在2个版本的Morris水任务中测试大鼠。 大脑中动脉闭塞的大鼠表现出显着的损害，在他们的能力，导航到一个隐藏的平台，但没有显着损害的可见（线索）版本的任务。 这种短暂的感觉运动和反射缺陷的一般模式，但具有更持久的认知障碍，与MCA梗死后在人类中观察到的相似。
Rats were subjected to either right proximal middle cerebral artery (MCA) occlusion or sham operation, and examined for an extended period on a battery of tests designed to measure simple motor function, sensorimotor integration and cognitive function. Rats with MCA occlusion showed extensive neuronal loss in the dorsolateral striatum and variable neuron loss in the parietal, temporal and frontolateral neocortex. MCA occluded animals exhibited significant impairments in tests of postural reflex, visual and tactile forelimb placing, locomotor coordination, and a test of simultaneous bilateral tactile extinction. The reflex and sensorimotor function deficits recovered to pre-operative levels by Day 30 post-ischemia. Five weeks following surgery, rats were tested in 2 versions of the Morris water task. Rats with MCA occlusion demonstrated significant impairments in their ability to navigate to a hidden platform, but were not significantly impaired on the visible (cued) version of the task. This general pattern of transient sensorimotor and reflex deficits, but with more persistent cognitive impairments, is similar to that seen in humans following MCA infarcts.