Hypomagnesemia in type 2 diabetes mellitus.
Hypomagnesemia in type 2 diabetes mellitus.
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DOI：
10.4103/2230-8210.103020
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发表时间：
2012-11
影响因子：
--
通讯作者：
Saikia UK
中科院分区：
文献类型：
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作者：
Dasgupta A;Sarma D;Saikia UK
低镁血症在2型糖尿病中有报道；镁缺乏可能在血管内皮功能障碍和胰岛素功能改变的发展中起作用。目的了解2型糖尿病非危重患者低镁血症的发生率，探讨低镁血症与血糖控制及糖尿病各种远期并发症的关系。对内科和内分泌科收治的150例非危重(APACHE评分)2型糖尿病患者因血糖控制不良和(或)各种糖尿病并发症进行研究。入院时对血清镁进行评估，并对被发现缺乏的患者进行复查。低镁血症17例(11.33%)，男女之比为9：8。低镁血症组平均糖化血红蛋白为11.9%，对照组为9.8%(P=0.0016)。低镁血症组视网膜病变、微量白蛋白尿、大量白蛋白尿、足部溃疡和神经病的发生率分别为45.8%(P=0.118)、38.34%(P=0.704)、15.03%(P=0.566)、22.55%(P=0.011)和82.7%(P=0.976)，分别为45.8%(P=0.118)、38.34%(P=0.704)、15.03%(P=0.566)、22.55%(P=0.011)和82.7%(P=0.976)。冠状动脉疾病在低镁血症组中较少见(17.6%比39%)，但在50年亚组中相似(27%比25%)(P=0.796)。糖尿病患者的低镁血症与血糖控制较差、视网膜病变、肾病和足部溃疡有关。
Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function. To assess the incidence of hypomagnesemia among noncritically ill patients of Type 2 diabetes mellitus and to evaluate the relation of hypomagnesemia to glycemic control and various long-term complications of diabetes mellitus. One hundred and fifty, noncritically ill (APACHE score < 10) type 2 diabetes mellitus patients, who were admitted in the Departments of Medicine and Endocrinology, GMCH for uncontrolled hyperglycemia and/or various diabetic complications were studied. Serum magnesium was assessed at admission and rechecked in those found to be deficient. Hypomagnesemia (Se magnesium < 1.6 mg/dl) was documented in 17 (11.33%) patients with a female:male ratio of 9:8. Mean HbA1c was 11.9% in the hypomagnesemic patients compared with 9.8% in controls (P =0.0016). Retinopathy, microalbuminuria, macroalbuminuria, foot ulceration, and neuropathy was present in 64%, 47%, 17.64%, 58.8%, and 82.35%, respectively, of the patients with hypomagnesemia as compared with 45.8% (P =0.118), 38.34% (P =0.704),15.03% (P =0.566), 22.55% (P =0.011) and 82.7% (P =0.976) without hypomagnesemia. Coronary artery disease was less common in the hypomagnesemia group (17.6% vs 39%), but comparable in the subgroup < 50 years (27% vs 25%) (P =0.796). Hypomagnesemia in diabetes was associated with poorer glycemic control, retinopathy, nephropathy, and foot ulcers.