Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes
Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes
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DOI：
10.5114/aoms.2019.87541
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发表时间：
2020-01-01
影响因子：
3.8
通讯作者：
Kotur-Stevuljevic, Jelena
中科院分区：
文献类型：
--
作者：
Klisic, Aleksandra;Kavaric, Nebojsa;Kotur-Stevuljevic, Jelena
简介：我们的目的是通过计算其综合评分来检测血清内皮素水平以及血脂异常、氧化应激（OS）和炎症的总体参与在患有前驱糖尿病和明显的2型糖尿病（T2 D）的受试者中与葡萄糖调节有关的血脂异常-氧合-炎症（DOI）评分。共有59例糖尿病前期患者和102例T2 D患者与117例无糖尿病对照进行了比较。检测糖化血红蛋白（HbA（1c））、炎症、OS和血脂参数。用单因素和多因素Logistic序贯回归分析临床资料与HbA（1c）水平的关系。HbA（1c）作为因变量在有序水平（即分别为< 5.7%、5.7- 6.4%、> 6.4%）给出。内皮聚糖浓度每升高1个单位，HbA（1c）浓度升高的概率增加3倍以上（OR = 3.69，95%CI：1.84-7.01，p < 0.001）。此外，血脂异常评分、氧合评分、炎症评分和DOI评分每增加1个单位，HbA（1c）浓度升高的概率分别增加19%、13%、51%和11%。在模型中，调整混杂变量后，endocan和DOI评分仍然是HbA（1c）水平的独立预测因子。结论：在糖尿病前期和显性T2 D患者中，Endocan和DOI评分与HbA（1c）独立相关。
Introduction: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D).Material and methods: A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA(1c)), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA(1c) level were tested with univariate and multivariate logistic ordinal regression analysis. HbA(1c) as a dependent variable is given at the ordinal level (i.e. < 5.7%; 5.7-6.4%, > 6.4%, respectively).Results: Endocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA(1c) concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84-7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA(1c) concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA(1c) level.Conclusions: Endocan and DOI score are independently correlated with HbA(1c) in patients with prediabetes and overt T2D.