Vitamin D and the brain: Genomic and non-genomic actions
Vitamin D and the brain: Genomic and non-genomic actions
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DOI：
10.1016/j.mce.2017.05.035
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发表时间：
2017-09-15
影响因子：
4.1
通讯作者：
Eyles, Darryl
中科院分区：
文献类型：
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作者：
Cui, Xiaoying;Gooch, Helen;Eyles, Darryl
1，25（OH）（2）D-3（维生素D）是公认的调节多种大脑功能的神经类固醇。越来越多的证据表明，维生素D在大脑发育、神经传递、神经保护和免疫调节中起着关键作用。然而，维生素D在大脑中发挥这些功能的精确分子机制仍不清楚。维生素D信号通过维生素D受体（VDR）发生，维生素D受体是核受体超家族中的一种锌指蛋白。像其他核类固醇一样，维生素D具有基因组和非基因组作用。维生素D的转录活性通过核VDR发生，当VDR分布在核外时，它的更快的非基因组作用可以发生。VDR存在于发育和成人大脑中，在那里它介导维生素D对大脑发育和功能的影响。本文综述了维生素D在脑中的基因组和非基因组作用的体外和体内研究进展。此外，我们将这些过程与功能性神经化学和行为结果联系起来。阐明维生素D在大脑中信号传导的精确分子机制可能有助于理解这种类固醇在大脑个体发育和功能中的作用。(C)2017爱思唯尔B. V.保留所有权利。
1,25(OH)(2)D-3 (vitamin D) is well-recognized as a neurosteroid that modulates multiple brain functions. A growing body of evidence indicates that vitamin D plays a pivotal role in brain development, neuro-transmission, neuroprotection and immunomodulation. However, the precise molecular mechanisms by which vitamin D exerts these functions in the brain are still unclear. Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Like other nuclear steroids, vitamin D has both genomic and non-genomic actions. The transcriptional activity of vitamin D occurs via the nuclear VDR Its faster, non-genomic actions can occur when the VDR is distributed outside the nucleus. The VDR is present in the developing and adult brain where it mediates the effects of vitamin D on brain development and function. The purpose of this review is to summarise the in vitro and in vivo work that has been conducted to characterise the genomic and non-genomic actions of vitamin D in the brain. Additionally we link these processes to functional neurochemical and behavioural outcomes. Elucidation of the precise molecular mechanisms underpinning vitamin D signalling in the brain may prove useful in understanding the role this steroid plays in brain ontogeny and function. (C) 2017 Elsevier B.V. All rights reserved.