Using connectome-based predictive modeling to predict individual behavior from brain connectivity.
Using connectome-based predictive modeling to predict individual behavior from brain connectivity.
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DOI:
10.1038/nprot.2016.178
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发表时间:
2017-03
期刊:
影响因子:
14.8
通讯作者:
Constable RT
中科院分区:
文献类型:
--
作者:
Shen X;Finn ES;Scheinost D;Rosenberg MD;Chun MM;Papademetris X;Constable RT
Neuroimaging is a fast developing research area where anatomical and functional images of human brains are collected using techniques such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and electroencephalography (EEG). Technical advances and large-scale datasets have allowed for the development of models capable of predicting individual differences in traits and behavior using brain connectivity measures derived from neuroimaging data. Here, we present connectome-based predictive modeling (CPM), a data-driven protocol for developing predictive models of brain-behavior relationships from connectivity data using cross-validation. This protocol includes the following steps: 1) feature selection, 2) feature summarization, 3) model building, and 4) assessment of prediction significance. We also include suggestions for visualizing the most predictive features (i.e., brain connections). The final result should be a generalizable model that takes brain connectivity data as input and generates predictions of behavioral measures in novel subjects, accounting for a significant amount of the variance in these measures. It has been demonstrated that the CPM protocol performs equivalently or better than most of the existing approaches in brain-behavior prediction. However, because CPM focuses on linear modeling and a purely data-driven driven approach, neuroscientists with limited or no experience in machine learning or optimization would find it easy to implement the protocols. Depending on the volume of data to be processed, the protocol can take 10–100 minutes for model building, 1–48 hours for permutation testing, and 10–20 minutes for visualization of results.
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影响因子:
5.7
作者:
Power JD;Schlaggar BL;Petersen SE
通讯作者:
Petersen SE
影响因子:
4.7
作者:
Khazaee, Ali;Ebrahimzadeh, Ata;Babajani-Feremi, Abbas
通讯作者:
Babajani-Feremi, Abbas
DOI:
10.1080/03610927708827533
发表时间:
1977-01-01
期刊:
COMMUNICATIONS IN STATISTICS PART A-THEORY AND METHODS
影响因子:
--
作者:
HOLLAND, PW;WELSCH, RE
通讯作者:
WELSCH, RE
影响因子:
25
作者:
Rosenberg MD;Finn ES;Scheinost D;Papademetris X;Shen X;Constable RT;Chun MM
通讯作者:
Chun MM
影响因子:
3
作者:
HD-200 Consortium
通讯作者:
HD-200 Consortium