Effects of Hange-koboku-to (Banxia-houpo-tang) on neuropeptide levels in human plasma and saliva.
Effects of Hange-koboku-to (Banxia-houpo-tang) on neuropeptide levels in human plasma and saliva.
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DOI：
10.1248/bpb.26.1609
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发表时间：
2003-11
影响因子：
2
通讯作者：
T. Naito;H. Itoh;M. Takeyama
中科院分区：
文献类型：
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作者：
T. Naito;H. Itoh;M. Takeyama
Hange-koboku-to（Banxia-houpo-tang）是一种中草药（汉方），已用于改善声音嘶哑，喉咙和/或食道中的异物感，以及吞咽反射等病症。经验效应的机制之一被认为是由于局部神经肽水平的局部变化。我们研究了Hange-koboku-to对血浆和唾液中的神经肽、降钙素基因相关肽（CGRP）、P物质、生长抑素和血管活性肠肽（VIP）的影响，以及对健康受试者唾液分泌的影响。与安慰剂相比，单次口服Hange-koboku-to导致血浆中P物质免疫反应物质（IS）（40 min）显著增加，血浆中CGRP-IS和生长抑素-IS略有增加。在唾液神经肽中，Hange-koboku-to引起P物质-IS（20分钟）和生长抑素-IS（40，60分钟）的显着增加，VIP-IS略有增加。然而，单次Hange-koboku-to刺激对唾液腺体积没有显著影响。这些结果似乎表明，Hange-koboku-to改善嘶哑的声音，异物感在喉咙和食道，吞咽反射障碍，通过刺激神经肽能神经局部。
Hange-koboku-to (Banxia-houpo-tang), a Chinese herbal (Kampo) medicine, has been used for improvement of hoarse voice, something foreign body sensation in the throat and/or esophagus, and swallowing reflex, among other conditions. One of the mechanisms of the empirical effects is assumed to be due to local changes in neuropeptide levels locally. We investigated the effects of Hange-koboku-to on neuropeptides, calcitonin gene-related peptide (CGRP), substance P, somatostatin, and vasoactive intestinal peptide (VIP) in plasma and saliva, as well as on salivary secretion in healthy subjects. A single oral administration of Hange-koboku-to caused significant increases in substance P-immunoreactive substance (IS) (40 min) in plasma, and slightly increased in CGRP-IS and somatostatin-IS in plasma compared with placebo. In saliva neuropeptides, Hange-koboku-to caused significant increases in substance P-IS (20 min) and somatostatin-IS (40, 60 min), and a slight increase in VIP-IS. However, a single Hange-koboku-to stimulation did not have a significant effect of sialosis volume. These results seem to suggest that Hange-koboku-to improves hoarse voice, something foreign body sensation in the throat and esophagus, and swallowing reflex disorder, by stimulation of neuropeptidergic nerves locally.