Toxic and genotoxic evaluation of six antibiotics on non-target organisms
Toxic and genotoxic evaluation of six antibiotics on non-target organisms
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DOI：
10.1016/j.scitotenv.2004.11.017
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发表时间：
2005-06-15
影响因子：
9.8
通讯作者：
Parrella, A
中科院分区：
文献类型：
--
作者：
Isidori, M;Lavorgna, M;Parrella, A
研究了以下六种抗生素对水生生物的生态毒性：红霉素、土霉素、磺胺甲恶唑、氧氟沙星、林可霉素和克拉霉素。对细菌、藻类、轮虫、微甲壳动物和鱼类进行了生物测定，以评估急性和慢性毒性，同时使用SOS Chromotest和艾姆斯试验检测所研究药物的遗传毒性潜力。对于风险评估，使用文献中关于其在水生环境中出现情况的现有数据和从生物测定中获得的毒性数据，通过MEC/PNEC比率计算环境影响。生态毒理学结果表明，急性毒性为mg/L，而对于慢性数据，抗生素在μ g/L的浓度下具有生物活性，主要是对藻类。调查的药物对轮虫和甲壳类动物的活性要低一个或两个数量级。氧氟沙星是唯一的遗传毒性化合物，磺胺甲恶唑、氧氟沙星和林可霉素具有致突变性。在环境风险方面，大环内酯类药物对水环境的危害最大。(c)2004 Elsevier B. V.保留所有权利。
The ecotoxicity of the following six antibiotics on aquatic organisms was investigated: Erythromycin, Oxytetracyclin, Sulfamethoxazole, Ofloxacin, Lincomycin and Clarithromycin. Bioassays were performed on bacteria, algae, rotifers, microcrustaceans and fish to assess acute and chronic toxicity, while SOS Chromotest and Ames test were used to detect the genotoxic potential of the investigated drugs. For risk assessment, the environmental impact was calculated by MEC/PNEC ratio using the available data from the literature regarding their occurrence in the aquatic environment and the toxicity data obtained from the bioassays performed. The ecotoxicological results showed that acute toxicity was in the order of mg/L while, for the chronic data the antibiotics were bioactive at concentrations in the order of mu g/L, mainly for the algae. Drugs investigated were one or two order of magnitude less active against rotifers and crustaceans. Ofloxacin was the only genotoxic compound and Sulfamethoxazole, Ofloxacin and Lincomycin were mutagenic. As for environmental risk, the macrolides were found to be the most harmful for the aquatic environment. (c) 2004 Elsevier B.V. All rights reserved.