Entomological Assessment of the Status and Risk of Mosquito-borne Arboviral Transmission in Ghana
Entomological Assessment of the Status and Risk of Mosquito-borne Arboviral Transmission in Ghana
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DOI：
10.3390/v12020147
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发表时间：
2020-02-01
期刊：
影响因子：
4.7
通讯作者：
Iwanaga, Shiroh
中科院分区：
文献类型：
--
作者：
Amoa-Bosompem, Michael;Kobayashi, Daisuke;Iwanaga, Shiroh
昆虫学监测是监测和控制媒介传播疾病的工具之一。然而，利用昆虫学监测控制虫媒病毒感染媒介往往依赖于发现受感染的个体。虽然这种方法在高流行地区可能足够，但在低流行地区和非流行地区，它在控制疾病传播方面效果不佳。在这项研究中，我们通过将蚊子监测与病毒分离和检测相结合，检验了使用昆虫学标记来评估加纳虫媒病毒感染状况和风险的效率，加纳被认为是一个非流行国家。这项研究报告了加纳存在的隐种蚊子，表明在蚊子监测中需要将形态学鉴定和分子技术结合起来。此外，虽然没有检测到医学上重要的病毒，但讨论了昆虫特异性病毒在理解病毒进化和虫媒病毒传播中的重要性。本研究首次报道了登革热病毒与双链RNA埃及伊蚊全抗病毒之间的相互关系。最后，本研究讨论了伊蚊和库蚊病毒的复杂性及其对虫媒病毒传播的启示。
Entomological surveillance is one of the tools used in monitoring and controlling vector-borne diseases. However, the use of entomological surveillance for arboviral infection vector control is often dependent on finding infected individuals. Although this method may suffice in highly endemic areas, it is not as effective in controlling the spread of diseases in low endemic and non-endemic areas. In this study, we examined the efficiency of using entomological markers to assess the status and risk of arbovirus infection in Ghana, which is considered a non-endemic country, by combining mosquito surveillance with virus isolation and detection. This study reports the presence of cryptic species of mosquitoes in Ghana, demonstrating the need to combine morphological identification and molecular techniques in mosquito surveillance. Furthermore, although no medically important viruses were detected, the importance of insect-specific viruses in understanding virus evolution and arbovirus transmission is discussed. This study reports the first mutualistic relationship between dengue virus and the double-stranded RNA Aedes aegypti totivirus. Finally, this study discusses the complexity of the virome of Aedes and Culex mosquitoes and its implication for arbovirus transmission.