Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression.
Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression.
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DOI：
10.1016/j.jpsychires.2016.12.011
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发表时间：
2017-04
影响因子：
4.8
通讯作者：
Goveas JS
中科院分区：
文献类型：
--
作者：
Li W;Wang Y;Ward BD;Antuono PG;Li SJ;Goveas JS
先前的研究表明，在晚年抑郁症（LLD）的核心神经认知网络（执行控制[ECN]，默认模式[DMN]和显着性[SN]网络）的功能障碍。LLD中是否存在网络间功能障碍性连接，以及这种中断是否与核心症状维度相关尚不清楚。对LLD（n=39）和年龄和性别等同的健康对照（HC）（n=29）参与者进行了横断面静息状态功能连接性磁共振成像研究。采用二元回归独立成分分析方法确定代表ECN、DMN和SN的成分。内在的网络间连接LLD和HC参与者之间进行了比较，网络间连接异常与尺寸测量的关系进行了检查。相对于HC参与者，LLD受试者显示出双侧ECN和默认模式皮质下（丘脑，基底神经节和腹侧纹状体）网络之间的网络间连接性降低，以及左侧ECN和SN突触组件;左侧ECN和后部DMN和显著性（背侧前扣带回）网络组件之间的网络间连接性增加。在LLD参与者中，不同的网络连接异常与抑郁和焦虑的严重程度以及执行功能障碍相关。LLD受试者也表现出明显的ECN内网络连接差异，而较少但显着的DMN和SN中断也被检测到。研究内在的网络间功能连接可以提供一个机制框架，以更好地理解LLD核心症状维度的神经基础。网络间的连接措施有可能成为包括LLD的症状维度的神经影像学生物标志物，并可能有助于开发特定于LLD的治疗算法。
Prior studies have demonstrated dysfunctions within the core neurocognitive networks (the executive control [ECN], default mode [DMN] and salience [SN] networks) in late-life depression (LLD). Whether inter-network dysfunctional connectivity is present in LLD, and if such disruptions are associated with core symptom dimensions is unknown. A cross-sectional resting-state functional connectivity magnetic resonance imaging investigation was conducted of LLD (n=39) and age- and gender-equated healthy comparison (HC) (n=29) participants. Dual regression independent component analysis approach was used to identify components that represented the ECN, DMN and SN. The intrinsic inter-network connectivity was compared between LLD and HC participants and the relationship of inter-network connectivity abnormalities with dimensional measures was examined. Relative to HC participants, LLD subjects showed decreased inter-network connectivity between the bilateral ECN and default mode subcortical (thalamus, basal ganglia and ventral striatum) networks, and the left ECN and SN insula component; and increased inter-network connections between the left ECN and posterior DMN and salience (dorsal anterior cingulate) network components. Distinct internetwork connectivity abnormalities correlated with depression and anxiety severity, and executive dysfunction in LLD participants. LLD subjects also showed pronounced intra-network connectivity differences within the ECN, whereas fewer but significant DMN and SN disruptions were also detected. Investigating the intrinsic inter-network functional connectivity could provide a mechanistic framework to better understand the neural basis that underlies core symptom dimensions in LLD. Inter-network connectivity measures have the potential to be neuroimaging biomarkers of symptom dimensions comprising LLD, and may assist in developing symptom-specific treatment algorithms.