Effect of single and repeated application of chlorhexidine varnish on mutans streptococci in plaque from fissures of premolar and molar teeth.
Effect of single and repeated application of chlorhexidine varnish on mutans streptococci in plaque from fissures of premolar and molar teeth.
复制标题
单次和重复使用洗必泰清漆对前磨牙和磨牙牙菌斑中变形链球菌的影响。
作者：
Y. Ie;M. Schaeken
本研究的目的是研究40%洗必泰涂膜1次和2次对磨牙和前磨牙牙裂菌斑中变异链球菌数量的影响。29名年龄在20-30岁的受试者参与了这项研究，并被随机分配到三组中的一组。在每个受试者中，选择了两个具有高水平突变链球菌的裂隙。第1组(对照组)用不含洗必泰的安慰剂涂膜。2组裂隙一次性涂抹40%洗必泰涂膜，而第3组裂隙在1周后再涂抹洗必泰涂膜。在第一次使用洗必泰清漆之前，以及随后的1、2和4个月，采集裂隙菌斑样本。与对照组相比，涂药后2个月和4个月，2组菌斑对变形链球菌的抑制作用显著，3组菌斑对变形链球菌的抑制作用最大。变形链球菌在前磨牙中的抑制作用比在磨牙中更强，在前磨牙牙缝中的抑制作用更强，持续时间更长。
The aim of this study was to determine the effects of one and two applications of 40% chlorhexidine varnish on the numbers of mutants streptococci in human dental fissure plaques from molar and premolar teeth. Twenty-nine subjects (aged 20-30 years) participated in the study and were randomly assigned to one of three groups. In each subject two fissures with high levels of mutants streptococci were selected. The fissures in group 1 (control group) were treated with placebo varnish containing no chlorhexidine. Fissures in group 2 received a single application of 40% chlorhexidine varnish, whereas fissures in group 3 received an additional chlorhexidine varnish application 1 week after the first application. Fissure plaque samples were taken prior to the first application of chlorhexidine varnish and subsequently 1, 2, and 4 months thereafter. Compared with the fissures in the control group, the suppression of mutans streptococci was significant in plaques from group 2 for up to 2 months and in plaques from group 3 for up to 4 months after application. Mutans streptococci were suppressed more strongly in premolar than in molar teeth and more strongly and for a longer period of time in fissures of premolar teeth treated twice than in fissures of premolars treated once.