Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide.
Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide.
复制标题
血清素受体、SERT mRNA 及其与酒精依赖和自杀男性症状的相关性。
DOI：
10.1111/j.1600-0447.2011.01816.x
复制
发表时间：
2012
影响因子：
6.7
通讯作者：
Delgado,PL
中科院分区：
文献类型：
--
作者：
Thompson,PM;Cruz,DA;Olukotun,DY;Delgado,PL
Thompson PM，Cruz DA，Olukotun DY，Delgado PL. 5-羟色胺受体、SERT mRNA及其与男性酒精依赖和自杀症状的相关性目的：本研究验证了前额叶皮质5-羟色胺（5-HT）系统成分异常与酒精依赖受试者自杀相关的假设。其次，我们评估了一生的冲动和情绪症状与前额叶皮质5-HT measures.Method的关系：组织从Brodmann的区域（BA）9和24在尸检样本的个人谁是酒精依赖自杀（n= 5），酒精依赖没有自杀（n= 9）和正常对照组（n= 5）。 测定5-羟色胺受体（5-HT）和5-羟色胺再摄取转运体（SERT）mRNA的表达。结果：无自杀的酒精依赖组BA 9区5-羟色胺受体1A（5 HT 1A）mRNA表达水平明显高于对照组。在酒精依赖伴自杀组中，焦虑症状与BA 24 SERT mRNA表达降低有关，抑郁症状与BA 9 5 HT 1A mRNA表达降低有关。在酒精依赖组中，冲动与BA 9和BA 24 5-羟色胺受体2A mRNA的增加相关。结论：我们的数据表明，酒精依赖和自杀涉及区域特异性变化，而不是整体5-羟色胺钝化。这也表明症状受到前额皮质5-羟色胺受体mRNA水平的不同影响。
Thompson PM, Cruz DA, Olukotun DY, Delgado PL. Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide.Objective:This study tested the hypothesis that abnormalities in components of the serotonin (5HT) system in the prefrontal cortex are associated with suicide in alcohol‐dependent subjects. Second, we assessed the relationship of lifetime impulsivity and mood symptoms with prefrontal cortex 5‐HT measures.Method:Tissue was obtained from Brodmann’s areas (BA) 9 and 24 in postmortem samples of individuals who were alcohol dependent with suicide (n= 5), alcohol dependent without suicide (n= 9) and normal controls (n= 5). Serotonin receptor (5HT) and serotonin reuptake transporter (SERT) mRNA were measured. Interviews with next of kin estimated lifetime impulsivity and mood symptoms in the last week of life.Results:Serotonin receptor 1A (5HT1A) mRNA in BA 9 was elevated in the alcohol dependence without suicide group compared with controls. In the alcohol dependence with suicide group, anxiety symptoms were associated with decreased BA 24 SERT mRNA and depressive symptoms with BA 9 5HT1A mRNA expression. In the alcohol dependent only group impulsivity is correlated with increased BA 9, and BA 24 serotonin receptor 2A mRNA.Conclusion:Our data suggest region‐specific change, rather than global serotonin blunting is involved in alcohol dependence and suicide. It also suggests that symptoms are differentially influenced by prefrontal cortex serotonin receptor mRNA levels.