INTERMITTENT SHEDDING OF HUMAN-IMMUNODEFICIENCY-VIRUS IN SEMEN - IMPLICATIONS FOR SEXUAL TRANSMISSION
INTERMITTENT SHEDDING OF HUMAN-IMMUNODEFICIENCY-VIRUS IN SEMEN - IMPLICATIONS FOR SEXUAL TRANSMISSION
复制标题
DOI：
10.1016/s0022-5347(01)66969-6
复制
发表时间：
1995-09-01
影响因子：
6.6
通讯作者：
COREY, L
中科院分区：
文献类型：
--
作者：
KRIEGER, JN;COOMBS, RW;COREY, L
目的：我们试图增加我们对人类免疫缺陷病毒（HIV）在精液中脱落的理解。材料和方法：我们通过HIV共培养对16名血清阳性男性进行了长达27个月的随访，其中一个子集使用聚合酶链反应进行了评估。至少1次HIV阳性精液培养的受试者比例从访视1时的3/16例（19%）增加至访视5时的10例（63%）。总体而言，114份标本中有25份（22%）培养出HIV。脱落是间歇性的10名男子，至少有1个阳性文化和精液脱落模式是高度可变的。结论：通过文化和聚合酶链反应，艾滋病毒是脱落间歇性的精液。如果培养进行得足够频繁，大多数血清反应阳性的男性会在精液中传播HIV。
Purpose: We attempt to increase our understanding of human immunodeficiency virus (HIV) shedding in semen.Materials and Methods: We followed 16 seropositive men for up to 27 months by HIV cocultivation, with a subset evaluated using the polymerase chain reaction.Results: The proportion with at least 1 HIV positive semen culture increased from 3 of 16 subjects (19%) at visit 1 to 10 (63%) by visit 5. Overall, HIV was cultured from 25 of 114 specimens (22%). Shedding was intermittent for each of the 10 men with at least 1 positive culture and seminal shedding patterns were highly variable.Conclusions: By culture and polymerase chain reaction, HIV is shed intermittently in the semen. If cultures are performed often enough most seropositive men shed HIV in the semen.