Aortic augmentation index is associated with the ankle-brachial index: A community-based study
Aortic augmentation index is associated with the ankle-brachial index: A community-based study
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DOI：
10.1016/j.atherosclerosis.2006.12.017
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发表时间：
2007-12-01
期刊：
影响因子：
5.3
通讯作者：
Kullo, Iftikhar J.
中科院分区：
文献类型：
--
作者：
Khaleghi, Mahyar;Kullo, Iftikhar J.
背景：动脉僵硬的增加与心血管事件的风险增加有关。我们调查了衡量动脉僵硬和波形反射的主动脉增强指数(AIX)和衡量外周动脉疾病(PAD)的踝臂指数(ABI)是否相关。方法：对475名无心脏病发作或中风病史(平均年龄59.3岁，46.5%的男性)的社区成年人进行了AIX和ABI的测量。通过压平眼压测量仪获得桡动脉脉搏波，并通过传递函数得到升主动脉压波。AIX是升主动脉压力波形的第一个和第二个收缩峰值之间的差值，以中心脉压为指标。ABI使用标准方案进行测量，有不可压缩血管(ABI>；1.5)的受试者被排除在分析之外。使用多变量线性和Logistic广义估计方程(GEE)分析来评估AIX是否与ABI和ABI相关
Background: Increased arterial stiffness has been associated with greater risk of cardiovascular events. We investigated whether aortic augmentation index (AIx), a measure of arterial stiffness and wave reflection, was associated with the ankle-brachial index (ABI), a measure of peripheral arterial disease (PAD).Method: AIx and ABI were measured in a community-based sample of 475 adults without prior history of heart attack or stroke (mean age 59.3 years, 46.5% men). Radial artery pulse waveforms were obtained by applanation tonometry and an ascending aortic pressure waveform derived by a transfer function. AIx is the difference between the first and second systolic peak of the ascending aortic pressure waveform indexed to the central pulse pressure. ABI was measured using a standard protocol, and subjects with non-compressible vessels (ABI >1.5) were excluded from the analyses. Multivariable linear and logistic generalized estimating equations (GEE) analyses were used to assess whether AIx was associated with ABI and ABI