An introduction to sequence similarity ("homology") searching.
An introduction to sequence similarity ("homology") searching.
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DOI：
10.1002/0471250953.bi0301s42
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发表时间：
2013-06
影响因子：
--
通讯作者：
Pearson, William R
中科院分区：
文献类型：
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作者：
Pearson, William R
序列相似性搜索，通常使用BLAST（单元3.3，3.4），是最广泛使用的，最可靠的，用于表征新确定的序列的策略。序列相似性搜索可以通过检测过度相似性来识别“同源”蛋白质或基因-统计学上显着的相似性反映了共同的祖先。本单元概述了从显著相似性推断同源性，并介绍了本章中的其他单元，这些单元提供了更多关于识别同源物的有效策略的细节。
Sequence similarity searching, typically with BLAST (units 3.3, 3.4), is the most widely used, and most reliable, strategy for characterizing newly determined sequences. Sequence similarity searches can identify ”homologous” proteins or genes by detecting excess similarity – statistically significant similarity that reflects common ancestry. This unit provides an overview of the inference of homology from significant similarity, and introduces other units in this chapter that provide more details on effective strategies for identifying homologs.