AWARD LECTURE Recent advances in process development for opiate-derived pharmaceutical agents
AWARD LECTURE Recent advances in process development for opiate-derived pharmaceutical agents
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颁奖讲座阿片类药物工艺开发的最新进展
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
T. Hudlický
中科院分区：
文献类型：
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作者：
T. Hudlický
这篇简短的综述总结了我们在从天然阿片剂如茶碱和东方滨合成丁丙诺啡、纳曲酮、纳洛酮和纳布芬的工艺开发方面所做的工作。在这项研究中，已经开发了几种新的吗啡N-脱甲基化方法。文章追溯了各种方法的演变，并对总体效率进行了比较。
This short review summarizes our work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as thebaine and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency.