Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches.
Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches.
复制标题
通过小鼠脊髓体内成像了解轴突对损伤的反应：两个分支的故事。
DOI：
10.1016/j.expneurol.2019.04.008
复制
发表时间：
2019
影响因子：
5.3
通讯作者：
Ma,Le
中科院分区：
文献类型：
--
作者：
Zheng,Binhai;Lorenzana,ArianaO;Ma,Le
了解哺乳动物中枢神经系统（CNS）中轴突如何对损伤做出反应的基本特性对于开发促进神经修复的策略具有根本价值。轴突具有复杂的形态，具有典型的分支模式。然而，目前的知识轴突损伤的反应很少考虑轴突分支，也没有策略，以促进轴突再生。本文综述了活体脊髓成像的证据，轴突分支显着影响损伤的退行性和再生反应。在一个主要的分叉点，取决于是否一个或两个轴突分支受伤，神经元可能会选择一个更自我保护的反应或更动态的反应。备用分支的稳定作用可能是神经元对损伤反应的众所周知的分歧的基础，并举例说明了一个例子，其中活体脊髓成像揭示了难以用常规组织学方法阐明的见解。
Understanding the basic properties of how axons respond to injury in the mammalian central nervous system (CNS) is of fundamental value for developing strategies to promote neural repair. Axons possess complex morphologies with stereotypical branching patterns. However, current knowledge of the axonal response to injury gives little consideration to axonal branches, nor do strategies to promote axon regeneration. This article reviews evidence fromin vivospinal cord imaging that axonal branches markedly impact the degenerative and regenerative responses to injury. At a major bifurcation point, depending on whether one or both axonal branches are injured, neurons may choose either a more self-preservative response or a more dynamic response. The stabilizing effect of the spared branch may underlie a well-known divergence in neuronal responses to injury, and illustrates an example wherein vivospinal cord imaging reveals insights that are difficult to elucidate with conventional histological methods.