Activation of submucosal 5‐HT3 receptors elicits a somatostatin‐dependent inhibition of ion secretion in rat colon
Activation of submucosal 5‐HT3 receptors elicits a somatostatin‐dependent inhibition of ion secretion in rat colon
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DOI：
10.1111/j.1476-5381.2010.00653.x
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发表时间：
2010-04
影响因子：
7.3
通讯作者：
N. Yang;Sm Liu;L. Zheng;T. Ji;Y. Li;XL Mi;H. Xue;W. Ren;J.‐D. Xu;Xh Zhang;L.‐S. Li;Y. Zhang;J-X Zhu
中科院分区：
文献类型：
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作者：
N. Yang;Sm Liu;L. Zheng;T. Ji;Y. Li;XL Mi;H. Xue;W. Ren;J.‐D. Xu;Xh Zhang;L.‐S. Li;Y. Zhang;J-X Zhu
背景与目的：5-羟色胺(5-羟色胺，5-HT3)是胃肠系统的关键调节物质，我们已发现粘膜下神经元5-HT3受体对结肠离子转运具有新的抑制作用。本研究的目的是探讨这种抑制作用的确切机制(S)。
Background and purpose: 5‐Hydroxytryptamine (5‐HT) is a key regulator of the gastrointestinal system and we have shown that submucosal neuronal 5‐HT3 receptors exerted a novel inhibitory effect on colonic ion transport. The aim of the present study was to investigate the precise mechanism(s) underlying this inhibitory effect.