Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus
Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus
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DOI：
10.1111/j.1399-0039.1997.tb02812.x
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发表时间：
1997-06-01
期刊：
影响因子：
--
通讯作者：
Gallagher, G
中科院分区：
文献类型：
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作者：
Eskdale, J;Wordsworth, P;Gallagher, G
最近的研究表明，IL-10水平在几种风湿性自身免疫性疾病中升高，特别是在系统性红斑狼疮(SLE)中。这种变化可能有遗传基础。我们研究了IL-10启动子区域的两个新的多态二核苷酸重复序列(IL10.G和IL10.R)，以探讨它们在56名高加索人SLE患者和102名种族匹配的对照组中与这种疾病相关的可能意义。结果表明，SLE患者和对照组在IL10.G微卫星上存在等位基因不平衡；这一观察结果得到了显著的基因分布差异的支持。自身抗体产生的性质和肾脏受累的有无似乎也与某些IL10.G微卫星等位基因有关，尽管个别临床亚组的小规模可能影响了这一结果。未观察到与IL10.R微卫星的关联。总体而言，在IL10G微卫星上观察到的SLE患者和对照组之间的差异表明，IL-10基因座对这种疾病的发生发展具有重要的遗传背景作用。尽管这项研究中描述的适度样本量需要仔细解释结果，但它们为未来的研究提供了一个有趣和有用的框架。
Recent studies have shown elevated IL-10 levels in several rheumatic autoimmune diseases, and particularly in systemic lupus erythematosus (SLE). Such changes may have a genetic basis. We studied two novel polymorphic dinucleotide repeats in the IL-10 promoter region (IL10.G and IL10.R) in order to investigate their possible significance in association with this condition in a group of 56 Caucasian SLE patients compared with 102 ethnically matched controls. The results show that there is an allelic imbalance between SLE patients and controls at the IL10.G microsatellite; this observation is supported by a significant difference in genotype distribution. The nature of autoantibody production and the presence or absence of renal involvement also appeared to be associated with certain IL10.G microsatellite alleles, although the small size of individual clinical sub-groupings may have influenced this result. No association with the IL10.R microsatellite was observed. Overall, the differences observed at the IL1O.G microsatellite between SLE patients and controls suggest that the IL-10 locus contributes to the genetic background important for the development of this disease. Although the moderate sample size described in this study requires that the results be interpreted carefully, they provide an interesting and useful framework for future study.