Development and Validation of a Short Version of the Kansas City Cardiomyopathy Questionnaire
Development and Validation of a Short Version of the Kansas City Cardiomyopathy Questionnaire
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DOI：
10.1161/circoutcomes.115.001958
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发表时间：
2015-09-01
影响因子：
6.9
通讯作者：
Jones, Philip G.
中科院分区：
文献类型：
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作者：
Spertus, John A.;Jones, Philip G.
在临床试验、质量评估计划和常规临床护理中，越来越多的人需要收集患者的健康状况（症状、功能和生活质量）经验。在心力衰竭中，23项疾病特异性堪萨斯城心肌病问卷（KCCQ）已被证明是有效、可靠的，对临床变化敏感，并可预测临床事件和费用。然而，它的使用在一定程度上受到其长度的限制。我们试图开发一个缩短版本的仪器，保持完整的KCCQ.Methods和结果的心理测量特性，从3个临床研究纳入4168例患者的数据，我们得出并验证了12项KCCQ，KCCQ-12，捕捉症状频率，身体和社会的限制，生活质量损害的结果，心力衰竭，以及整体的总结评分。KCCQ-12评分与原始量表高度相关（所有临床环境中所有量表>0.93），重测信度高（所有域>0.76），高响应性（出院后改善16-31分;标准化反应平均值=0.61-1.12），与完整的KCCQ相比，KCCQ-12具有可比的预后意义和临床重要差异的解释。项目工具，应该更可行的实施，同时保留完整的工具的心理测量特性。
Background There is a growing demand to collect patients' experiences of their health status (their symptoms, function, and quality of life) in clinical trials, quality assessment initiatives, and in routine clinical care. In heart failure, the 23-item, disease-specific Kansas City Cardiomyopathy Questionnaire (KCCQ) has been shown to be valid, reliable, sensitive to clinical change, and prognostic of both clinical events and costs. However, its use has been limited, in part, by its length. We sought to develop a shortened version of the instrument that maintains the psychometric properties of the full KCCQ.Methods and Results Using data from 3 clinical studies incorporating 4168 patients, we derived and validated a 12-item KCCQ, the KCCQ-12, to capture symptom frequency, physical and social limitations, and quality of life impairment as a result of heart failure, as well as an overall summary score. The KCCQ-12 scores had high correlations with the original scales (>0.93 for all scales in all clinical settings), high test-retest reliability (>0.76 for all domains), high responsiveness (16-31 point improvements after discharge from hospitalization; standardized response mean =0.61-1.12), and comparable prognostic significance and interpretation of clinically important differences as compared with the full KCCQ.Conclusions The KCCQ-12 is a shorter version of the original 23-item instrument that should be more feasible to implement while preserving the psychometric properties of the full instrument.