Microbiome response to diet: focus on obesity and related diseases
Microbiome response to diet: focus on obesity and related diseases
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DOI：
10.1007/s11154-020-09572-7
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发表时间：
2020-07-20
影响因子：
8.2
通讯作者：
Neyrinck, Audrey M.
中科院分区：
文献类型：
--
作者：
Delzenne, Nathalie M.;Rodriguez, Julie;Neyrinck, Audrey M.
在人类和动物模型中的大量研究描述了与肥胖和代谢综合征的特征相关的肠道微生物生态系统的紊乱，包括肝脏和心血管疾病。微生物组的操作在很大程度上受到饮食的影响，似乎是预防或控制肥胖和相关疾病的一种创新治疗工具。这篇综述描述了营养对肠道微生物区系组成和/或功能的影响，以及当可用时对宿主生理的影响。特别强调细菌衍生的代谢物在调节关键的肠道功能中的作用，这可能解释了它们的全身效应。
Numerous studies in humans and animal models describe disturbances of the gut microbial ecosystem associated with adiposity and hallmarks of the metabolic syndrome, including hepatic and cardiovascular diseases. The manipulation of the microbiome, which is largely influenced by the diet, appears as an innovative therapeutic tool to prevent or control obesity and related diseases. This review describes the impact of nutrients on the gut microbiota composition and/or function and when available, the consequences on host physiology. A special emphasis is made on the contribution of bacterial-derived metabolites in the regulation of key gut functions that may explain their systemic effect.