fMRI of emotional responses to odors: influence of hedonic valence and judgment, handedness, and gender
fMRI of emotional responses to odors: influence of hedonic valence and judgment, handedness, and gender
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DOI：
10.1016/s1053-8119(03)00388-4
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发表时间：
2003-10-01
期刊：
影响因子：
5.7
通讯作者：
Segebarth, C
中科院分区：
文献类型：
--
作者：
Royet, JP;Plailly, J;Segebarth, C
以前的正电子发射断层扫描研究表明，右利手的人，左眶额皮质是主导过程中的情绪处理气味。我们收集了28名受试者的功能磁共振成像数据，研究这个网络作为气味享乐价（愉快与不愉快）的函数，积极的享乐判断与消极的感觉享乐充电的气味，利手。和性别。进行了两次功能运行，在不同时期呈现令人愉快和不愉快的气味。在第一次运行中，受试者被动地闻到气味，而在第二次运行中，他们通过使用模拟视觉评级量表的“手指跨度”技术来评定气味的愉快或不愉快程度。同时记录皮肤电和体积描记反应，以控制情绪反应的隐蔽生理表现。梨状杏仁核区和腹侧杏仁核对不愉快的气味比愉快的气味更敏感。更极端的评级也与更高的electrodermall振幅，这表明，激活源于更多的情绪或享乐强度比价，不愉快的气味比愉快的气味引起更多的唤醒。令人不快的气味激活右撇子的左腹侧皮层和左撇子的右腹侧皮层，这表明情绪气味的偏侧化处理是利手的一个功能。积极的气味愉悦的决定诱导特定的左眶额皮质激活，暗示这方面的作用，在有意识的评估气味的情感质量。最后，左眶额皮质在女性中比男性更活跃，这可能与女性在气味识别方面的优势有关。(C)2003年爱思唯尔公司All rights reserved.
Previous positron emission tomography studies of right-handed individuals show that the left orbitofrontal cortex is dominant during emotional processing of odors. We collected functional magnetic resonance imaging data from 28 subjects to study this network as a function of odor hedonic valence (pleasant vs. unpleasant), active hedonic judgments versus passive sensation of hedonically charged odors, handedness. and gender. Two functional runs were performed, with pleasant and unpleasant odors presented in different epochs. In the first run, subjects passively smelled odorants, whereas in the second run they rated degree of odor pleasantness or unpleasantness by using a "finger-span" technique that simulated a visual rating scale. Electrodermal and plethysmography responses were simultaneously recorded to control for covert, physiological manifestations of the emotional response. The piriform-amygdala area and ventral insula were activated more for unpleasant than pleasant odors. More extreme ratings were also associated with higher electrodermall amplitude, suggesting that activation stemmed more from emotional or hedonic intensity than valence, and that unpleasant odors induced more arousal than pleasant odors. Unpleasant odors activated the left ventral insula in right-handers and the right ventral insula in left-handers, suggesting lateralized processing of emotional odors as a function of handedness. Active decisions about odor pleasantness induced specific left orbitofrontal cortex activation, implicating the role of this area in the conscious assessment of the emotional quality of odors. Finally, left orbitofrontal cortex was more active in women than men, potentially in relation to women's well-documented advantage in odor identification. (C) 2003 Elsevier Inc. All rights reserved.