Fatigue in primary biliary cirrhosis
Fatigue in primary biliary cirrhosis
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DOI：
10.1136/gut.43.5.705
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发表时间：
1998-11-01
期刊：
影响因子：
24.5
通讯作者：
Heathcote, EJ
中科院分区：
文献类型：
--
作者：
Cauch-Dudek, K;Abbey, S;Heathcote, EJ
背景疲劳是原发性胆汁性肝硬化（PEC）患者常见的衰弱症状，目的是研究疲劳与睡眠、抑郁和肝病严重程度的关系。方法PBC患者完成有效的自我报告问卷，测量疲劳、睡眠质量、抑郁和功能能力。记录了口头报告的疲劳和观察员评定的抑郁和熊去氧胆酸（UDCA）使用情况。肝脏生化和测试，以排除疲劳的代谢causeswerenched.Results-Mean年龄的88例患者入组为57岁，86%为女性，平均病程为6.6年。中位胆红素为13 μ mol/l（平均18.6）。60名患者（68%）口头报告疲劳（超过6个月）。自评疲劳严重程度评分（FSS）与口头报告的疲劳相关性良好（p=0.0001）。FSS与年龄、病程、血清胆红素、马约风险评分或UDCA使用无关，但与睡眠质量相关。疲劳患者比非疲劳患者有更多的睡眠问题和更高的抑郁评分。自评抑郁症是目前在28%（17/60）的疲劳与4%（1/28）的非疲劳患者;结论长期疲劳影响68%的PBC患者，但它是不相关的严重程度，他们的肝脏疾病。睡眠质量差和抑郁通常与疲劳有关。
Background-Fatigue is a frequent and debilitating symptom in patients with primary biliary cirrhosis (PEC).Aims-To study fatigue in relation to sleep, depression, and liver disease severity.Methods-Patients with PBC completed validated self report questionnaires measuring fatigue, sleep quality, depression, and functional capacity. Verbally reported fatigue and observer rated measure of depression and ursodeoxycholic acid (UDCA) use were recorded. Liver biochemistry and tests to rule out metabolic causes of fatigue were performed.Results-Mean age of the 88 patients enrolled was 57 years; 86% were female and mean duration of disease was 6.6 years. Median bilirubin was 13 mu mol/l (mean 18.6). Verbally reported fatigue (for more than six months) was present in 60 patients (68%). The self rated Fatigue Severity Score (FSS) correlated well with verbally reported fatigue (p=0.0001). The FSS did not correlate with age, duration of disease, serum bilirubin, Mayo Risk Score, or UDCA use, but correlation was seen with sleep quality. Fatigued patients had more sleep problems and higher depression scores than non-fatigued patients. Self rated depression was present in 28% (17/60) of fatigued compared with 4% (1/28) of non-fatigued patients;Conclusions-Long term fatigue affected 68% of the patients with PBC but it was not related to the severity of their liver disease. Poor sleep quality and depression were commonly associated with fatigue.