Dopamine sensing with robust carbon nanotube implanted polymer micropillar array electrodes fabricated by coupling micromolding and infiltration coating processes
Dopamine sensing with robust carbon nanotube implanted polymer micropillar array electrodes fabricated by coupling micromolding and infiltration coating processes
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DOI：
10.1016/j.electacta.2020.137632
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发表时间：
2021-02-01
影响因子：
6.6
通讯作者：
Wang, Shengnian
中科院分区：
文献类型：
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作者：
Chang, An-Yi;Liu, Xuan;Wang, Shengnian
柔性电化学传感器优选用于监测神经递质的水平，这对于理解人类中枢神经系统和诊断/治疗许多脑相关疾病是重要的。坚固的导电涂层对于这些神经传感器提高其灵敏度和选择性是必不可少的。通过耦合微图案成型和渗透涂层工艺，我们成功地制造了复合电极与碳纳米管（CNT）的一部分暴露于样品，而其余的嵌入在聚合物微柱和传感器的基础。与微柱阵列图案一起，部分植入配置为电极提供了在7天阻抗测试中具有最小电导率损失的稳定涂层。循环伏安法研究表明多巴胺的准可逆行为和保留93%的信号后，两个小时的污垢实验。当通过差分脉冲伏安法（DPV）检测多巴胺时，其表现出0.77 nM的检测限，2.34 nM的定量限和0.453 nA/nM的灵敏度。当检测多巴胺时，观察到分离良好的DPV峰，而不含和含有过量的尿酸、抗坏血酸和葡萄糖（常见的干扰生物活性化合物）。鉴于在刚性和柔性基底表面上的成功演示，这种新的制造方法及其传感器产品可以帮助推进重要的体内神经递质传感和其他电化学应用。出版社：Elsevier Ltd
Flexible electrochemical sensors are preferred to monitor the levels of neurotransmitters which are important to understand human central nervous system and diagnose/treat many brain-related diseases. Robust conductive coating is essential for these neural sensors to promote their sensitivity and selectivity. By coupling micropattern molding and infiltration coating processes, we successfully fabricated composite electrodes with part of carbon nanotubes (CNT) exposed to the sample while the rest of it embedded in polymer micropillars and the sensor base. Together with the micropillar array pattern, the partial implantation configuration provides the electrodes a stable coating with minimal conductivity loss in a 7-day impedance test. Cyclic voltammetric studies indicate a quasi-reversible behavior of dopamine and a retention of 93% signal after a two-hour fouling experiment. When detecting dopamine via differential pulse voltammetry (DPV), it exhibits a detection limit of 0.77 nM, quantification limit of 2.34 nM, and sensitivity of 0.453 nA/nM. Well separated DPV peaks were observed when sensing dopamine without and with excess uric acid, ascorbic acid, and glucose, common interfering bioactive compounds. Given successful demonstration on both rigid and soft substrate surfaces, this new fabrication method and its sensor products could help advance important in vivo neurotransmitter sensing and other electrochemical applications. Published by Elsevier Ltd.