Sweetened beverage consumption and risk of coronary heart disease in women
Sweetened beverage consumption and risk of coronary heart disease in women
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DOI：
10.3945/ajcn.2008.27140
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发表时间：
2009-04-01
影响因子：
7.1
通讯作者：
Hu, Frank B.
中科院分区：
文献类型：
--
作者：
Fung, Teresa T.;Malik, Vasanti;Hu, Frank B.
背景：以前的研究已经将全卡路里加糖饮料(SSB)与体重增加和2型糖尿病风险增加联系在一起。目的：我们前瞻性地研究了SSB的消费与女性冠心病(CHD)风险之间的关系。设计：从1980年到2004年，跟踪调查了护士健康研究中年龄为34-59岁的女性(n=88,520)，这些女性之前没有被诊断为冠心病(CHD)、中风或糖尿病。SSB的消费量来自1980至2002年间重复进行的7份食物频率调查问卷。应用COX比例风险模型计算冠心病的相对危险度(RR)，并对已知的心血管疾病危险因素进行调整。结果：在24年的随访中，我们确定了3105例冠心病(非致命性心肌梗死和致死性冠心病)的发病。在调整了标准和饮食危险因素后，根据SSB的累积平均摄入量(=2份/d)分类，冠心病的相对危险度(和95%CI)分别为1.0、0.96(0.87、1.0 6)、1.0 4(0.95、1.14)、1.2 3(1.06、1.43)和1.35(1.07、1.69)(趋势与t；0.001)。对体重指数、能量摄入量和糖尿病事件的额外调整减弱了这种关联，但它们仍然显著。人工加糖饮料与冠心病无关。结论：即使在考虑了其他不健康的生活方式或饮食因素后，经常饮用SSB仍与女性患CHD的风险增加有关。AM J Clin Nutr 2009；89：1037-42。
Background: Previous studies have linked full-calorie sugar-sweetened beverages (SSBs) with greater weight gain and an increased risk of type 2 diabetes.Objective: We prospectively examined the association between consumption of SSBs and the risk of coronary heart disease (CHD) in women.Design: Women (n = 88,520) from the Nurses' Health Study aged 34-59 y, without previously diagnosed coronary heart disease (CHD), stroke, or diabetes in 1980, were followed from 1980 to 2004. Consumption of SSBs was derived from 7 repeated food-frequency questionnaires administered between 1980 and 2002. Relative risks (RRs) for CHD were calculated by using Cox proportional hazards models and adjusted for known cardiovascular disease risk factors.Results: During 24 y of follow-up, we ascertained 3105 incident cases of CHD (nonfatal myocardial infarction and fatal CHD). After standard and dietary risk factors were adjusted for, the RRs (and 95% CIs) of CHD according to categories of cumulative average of SSB consumption (= 2 servings/ d) were 1.0, 0.96 (0.87, 1.06), 1.04 (0.95, 1.14), 1.23 (1.06, 1.43), and 1.35 (1.07, 1.69) (P for trend < 0.001). Additional adjustment for body mass index, energy intake, and incident diabetes attenuated the associations, but they remained significant. Artificially sweetened beverages were not associated with CHD.Conclusion: Regular consumption of SSBs is associated with a higher risk of CHD in women, even after other unhealthful lifestyle or dietary factors are accounted for. Am J Clin Nutr 2009; 89: 1037-42.