Association between obesity and psychiatric disorders in the US adult population
Association between obesity and psychiatric disorders in the US adult population
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DOI：
10.1001/archpsyc.63.7.824
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发表时间：
2006-07-01
影响因子：
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通讯作者：
Kessler, Ronald C.
中科院分区：
文献类型：
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作者：
Simon, Gregory E.;Von Korff, Michael;Kessler, Ronald C.
背景：流行病学数据表明肥胖和抑郁之间存在关联，但不同研究的结果不同，并且表明女性比男性的关系更强。目的：评估美国普通人群中肥胖与一系列情绪、焦虑和物质使用障碍之间的关系。设计：横断面流行病学调查。背景：美国成年人的全国代表性样本。参与者：共有9125名受访者提供了有关精神障碍、身高和体重的完整数据。有效率为70.9%。主要结果测量：参与者完成了一次面对面访谈，包括对一系列精神障碍的评估（使用世界卫生组织综合国际诊断访谈进行评估）以及身高和体重（通过自我报告）。结果：肥胖（定义为体重指数[以体重公斤除以身高米的平方计算]>= 30）与重度抑郁症（优势比[OR]， 1.21； 95%可信区间[CI]， 1.09-1.35）、双相情感障碍（OR, 1.47; 95% CI, 1.12-1.93）、恐慌症或广场恐怖症（OR, 1.27; 95% CI, 1.01-1.60）的终生诊断显著增加相关。肥胖与物质使用障碍终生风险显著降低相关（OR, 0.78; 95% CI, 0.65-0.93）。亚组分析发现，这些关联在男性和女性之间没有差异，但肥胖和情绪障碍之间的关联在非西班牙裔白人（OR, 1.38; 95% CI, 1.20-1.59）和大学毕业生（OR, 1.44; 95% CI, 1.14-1.81）中最强。结论：肥胖与情绪和焦虑障碍的几率增加约25%以及物质使用障碍的几率减少约25%相关。不同人口群体之间的差异表明，社会或文化因素可能会缓和或调节肥胖与情绪障碍之间的联系。
Background: Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men.Objective: To evaluate the relationship between obesity and a range of mood, anxiety, and substance use disorders in the US general population.Design: Cross-sectional epidemiologic survey.Setting: Nationally representative sample of US adults.Participants: A total of 9125 respondents who provided complete data on psychiatric disorder, height, and weight. Response rate was 70.9%.Main Outcome Measures: Participants completed an in-person interview, including assessment of a range of mental disorders (assessed using the World Health Organization Composite International Diagnostic Interview) and height and weight (by self-report).Results: Obesity (defined as body mass index [calculated as weight in kilograms divided by the square of height in meters] of >= 30) was associated with significant increases in lifetime diagnosis of major depression (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.09-1.35), bipolar disorder (OR, 1.47; 95% CI, 1.12-1.93), and panic disorder or agoraphobia (OR, 1.27; 95% CI, 1.01-1.60). Obesity was associated with significantly lower lifetime risk of substance use disorder(OR, 0.78; 95% CI, 0.65-0.93). Sub group analyses found no difference in these associations between men and women, but the association between obesity and mood disorder was strongest in non-Hispanic whites (OR, 1.38; 95% CI, 1.20-1.59) and college graduates (OR, 1.44; 95% CI, 1.14-1.81).Conclusions: Obesity is associated with an approximately 25% increase in odds of mood and anxiety disorders and an approximately 25% decrease in odds of substance use disorders. Variation across demographic groups suggests that social or cultural factors may moderate or mediate the association between obesity and mood disorder.