Prior experience conditionally inhibits the expression of new learning in Drosophila.
Prior experience conditionally inhibits the expression of new learning in Drosophila.
复制标题
DOI：
10.1016/j.cub.2021.05.056
复制
发表时间：
2021-08-23
期刊：
影响因子：
--
通讯作者：
Waddell S
中科院分区：
文献类型：
--
作者：
Jacob PF;Vargas-Gutierrez P;Okray Z;Vietti-Michelina S;Felsenberg J;Waddell S
Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. Here, we show that prior odor exposure can produce context-dependent LI of later appetitive olfactory memory performance in Drosophila. Odor pre-exposure forms a short-lived aversive memory whose lone expression lacks context-dependence. Acquisition of odor pre-exposure memory requires aversively reinforcing dopaminergic neurons that innervate two mushroom body compartments—one group of which exhibits increasing activity with successive odor experience. Odor-specific responses of the corresponding mushroom body output neurons are suppressed, and their output is necessary for expression of both pre-exposure memory and LI of appetitive memory. Therefore, odor pre-exposure attaches negative valence to the odor itself, and LI of appetitive memory results from a temporary and context-dependent retrieval deficit imposed by competition with the parallel short-lived aversive memory. Odor pre-exposure alters the expression of a learned association of that odor Pre-exposure memory only affects subsequent retrieval if context is consistent Pre-exposure memory can complement or compete with a learned association Odor pre-exposure forms a labile mushroom body-dependent aversive memory Jacob et al. show that prior experience of an odor can inhibit the retrieval of a newly formed memory for that same odor. Odor pre-exposure forms a labile mushroom body-dependent aversive memory that competes with expression of new learning if the context is appropriate. This study explains how a retrieval defect can underlie latent inhibition.
登录
查看更多内容
DOI：
10.1016/j.cub.2008.08.071
发表时间：
2008-11-11
期刊：
Current biology : CB
影响因子：
--
作者：
DasGupta S;Waddell S
通讯作者：
Waddell S
影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
2.7
作者：
DELACASA, G;LUBOW, RE
通讯作者：
LUBOW, RE
影响因子：
2.8
作者：
Dolzer, J;Fischer, K;Stengl, M
通讯作者：
Stengl, M
DOI：
10.1523/jneurosci.4145-12.2013
发表时间：
2013-03-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bazhenov M;Huerta R;Smith BH
通讯作者：
Smith BH