Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus
Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus
复制标题
DOI：
10.1016/j.metabol.2009.10.005
复制
发表时间：
2010-06-01
影响因子：
9.8
通讯作者：
Nishizawa, Yoshiki
中科院分区：
文献类型：
--
作者：
Emoto, Masanori;Mori, Katsuhito;Nishizawa, Yoshiki
胎儿蛋白a是一种多功能循环糖蛋白。在其作用中，抑制异位钙化是一个突出的特点。透析患者的低胎儿素a水平与心血管死亡率相关，可能是通过加速血管钙化。然而，除了透析条件外，胎儿素a水平与血管钙化之间的相关性仍然存在争议。此外，与经常在透析患者中发现的对内侧动脉钙化的作用相比，胎儿蛋白a对动脉粥样硬化钙化斑块（CPs）的抑制作用尚不清楚。因此，我们研究了胎儿素a水平与动脉粥样硬化性CPs之间的关系。在这项研究中，我们对416例连续无肾功能障碍的2型糖尿病患者进行了检查。我们测量了血清胎儿素a水平，并使用超声检查了颈总动脉和股动脉中CP的存在。CP患者的Fetuin-A水平明显低于无CP患者（分别为262.6 +/- 56.7和281.5 +/- 64.6 mu g/mL, P = 0.001）。多因素logistic回归分析显示，胎儿素a水平与CP的存在呈负相关（优势比为0.753；95%可信区间为0.608 ~ 0.933;P = 0.010）。这些结果表明，胎儿蛋白a可能独立于透析条件抑制动脉粥样硬化斑块的钙化。(C) 2010爱思唯尔公司版权所有。
Fetuin-A is a multifunctional circulating glycoprotein. Among its roles, inhibition of ectopic calcification is a prominent feature. Low fetuin-A levels in dialysis patients are associated with cardiovascular mortality, possibly via accelerating vascular calcification. However, except for dialyzed conditions, a correlation between fetuin-A levels and vascular calcification remains controversial. Furthermore, any inhibitory effect of fetuin-A on atherosclerotic calcified plaques (CPs) remains unclear compared with its effect on medial artery calcification that is often found in dialyzed patients. Therefore, we examined the association between fetuin-A levels and atherosclerotic CPs. For this study, 416 consecutive patients with type 2 diabetes mellitus and without renal dysfunction were examined. We measured serum fetuin-A levels and investigated for the presence of CP in the common carotid and femoral arteries using ultrasonography. Fetuin-A levels were significantly lower in patients with CP than those without CP (262.6 +/- 56.7 and 281.5 +/- 64.6 mu g/mL, respectively; P = .001). Multivariate logistic regression analysis showed that fetuin-A levels were inversely associated with the presence of CP (odds ratio = 0.753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition. (C) 2010 Elsevier Inc. All rights reserved.