MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila.
MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila.
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DOI：
10.1523/jneurosci.4004-12.2013
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发表时间：
2013-03-27
期刊：
影响因子：
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通讯作者：
Dubnau J
中科院分区：
文献类型：
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作者：
Li W;Cressy M;Qin H;Fulga T;Van Vactor D;Dubnau J
microRNA-mediated gene regulation plays a key role in brain development and function. But there are few cases in which the roles of individual miRNAs have been elucidated in behaving animals. We report a miR-276a::DopR regulatory module in Drosophila that functions in distinct circuits for naïve odor responses and conditioned odor memory. Drosophila olfactory aversive memory involves convergence of the odors (conditioned stimulus, CS) and the electric shock (unconditioned stimulus, US) in mushroom body (MB) neurons. Dopamine receptor, DopR, mediates the US inputs onto MB. Distinct dopaminergic neurons also innervate ellipsoid body (EB), where DopR function modulates arousal to external stimuli. We demonstrate that miR-276a is required in MB neurons for memory formation and in EB for naïve responses to odors. Both roles of miR-276a are mediated by tuning DopR expression. The dual role of this miR-276a::DopR genetic module in these two neural circuits highlights the importance of miRNA-mediated gene regulation within distinct circuits underlying both naïve behavioral responses and memory.
