The continued use of sunscreen prevents the development of actinic keratosis in aged Japanese subjects.
The continued use of sunscreen prevents the development of actinic keratosis in aged Japanese subjects.
复制标题
持续使用防晒霜可以防止日本老年人出现光化性角化病。
DOI：
10.1111/exd.13081
复制
发表时间：
2016
期刊：
影响因子：
3.6
通讯作者：
Yamamoto Y
中科院分区：
文献类型：
--
作者：
Kunimoto K;Furukawa F;Uede M;Mizuno M;Yamamoto Y
众所周知，光化性角化病（AK）的触发主要取决于紫外线照射。我们评估了长期使用防晒霜对老年患者AK组织病理学和皮肤镜变化的影响。使用防晒霜18个月后，光化性角化病的数量没有变化，组织学分级也没有提高。尽管在使用防晒霜18个月的受试者中，p53、Ki‐67和COX‐2阳性细胞的数量没有明显减少，但观察到这些蛋白的下降趋势。使用Chalkley方法，防晒霜的持续使用显著减少了CD31阳性血管的数量，皮肤镜研究发现，结垢和血管点有显著改善。此外，还发现防晒霜的使用量与光化性角化病的数量之间存在关系。考虑到这些结果，我们认为使用防晒霜可以降低AK向更高级别AK和鳞状细胞癌发展的风险。
It is well known that the trigger for actinic keratosis (AK) mainly depends on UV exposure. We evaluated the effects of long‐term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advancement of histological grade. Although a significant decrease was not observed in the number of positive cells of p53, Ki‐67 and COX‐2 of the subjects who used sunscreen for 18 months, the downward tendencies of these proteins were observed. The continued use of sunscreen decreased the number of CD31‐positive vessels significantly using the Chalkley method, and a significant improvement in scaling and vessel dots was found by dermoscopic study. Moreover, a relationship was found in the amount of sunscreen use and the number of actinic keratoses. Considering these results, it was thought that application of sunscreen reduces the risk of advancement of AK to higher grade AK and squamous cell carcinoma.