Diversity, evolution and population dynamics of avian influenza viruses circulating in the live poultry markets in China
Diversity, evolution and population dynamics of avian influenza viruses circulating in the live poultry markets in China
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DOI：
10.1016/j.virol.2017.02.009
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发表时间：
2017-05-01
期刊：
影响因子：
3.7
通讯作者：
Zhang, Yong-Zhen
中科院分区：
文献类型：
--
作者：
Chen, Liang-Jun;Lin, Xian-Dan;Zhang, Yong-Zhen
活禽市场（LPM）是新型禽流感病毒（AIV）的重要来源。 2015-2016 年期间，我们调查了中国湖北、浙江和江西省 10 个 LPM 的 AIV 多样性。在这些省份的 LPM 中观察到 AIV 的高度多样性和流行率（总共 12 种亚型）。然而，引人注目的是，2015 年至 2016 年期间发现的亚型与我们一年前在这些相同地点报告的亚型明显不同，这表明病毒遗传多样性在一年内发生了动态变化。系统发育分析揭示了频繁的重配，包括高致病性和低致病性AIV亚型之间以及在家禽和野生鸟类中传播的亚型之间的重配。值得注意的是，新型 H5N6 重配病毒包含一组类似 H9N2 的内部基因，在调查的所有三个地区都很流行。总体而言，这些数据突显了在 LPM 中循环的 AIV 的遗传多样性和重配模式的深刻变化。
Live poultry markets (LPMs) are an important source of novel avian influenza viruses (AIV). During 2015-2016 we surveyed AIV diversity in ten LPMs in Hubei, Zhejiang and Jiangxi provinces, China. A high diversity and prevalence of AIVs (totaling 12 subtypes) was observed in LPMs in these provinces. Strikingly, however, the subtypes discovered during 2015-2016 were markedly different to those reported by us in these same localities one year previously, suggesting a dynamic shift in viral genetic diversity over the course of a single year. Phylogenetic analyses revealed frequent reassortment, including between high and low pathogenic AIV subtypes and among those that circulate in domestic and wild birds. Notably, the novel H5N6 reassortant virus, which contains a set of H9N2-like internal genes, was prevalent in all three regions surveyed. Overall, these data highlight the profound changes in genetic diversity and in patterns of reassortment in those AIVs that circulate in LPMs.