Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis
Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis
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DOI：
10.1515/cclm-2015-0079
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发表时间：
2015-10-01
影响因子：
6.8
通讯作者：
Balog, Attila
中科院分区：
文献类型：
--
作者：
Legany, Nora;Toldi, Gergely;Balog, Attila
背景资料：尿激酶型纤溶酶原激活物受体（uPAR）是纤溶系统的一个重要组成部分，参与细胞外基质重塑和血管生成。新的动物模型支持uPAR不仅在纤维化中而且在系统性硬化症（SSc）相关的微血管异常中的关键作用。本研究的目的是探讨血浆可溶性uPAR（suPAR）在SSc中的水平，及其与器官特异性involvement.Methods：suPAR浓度测定SSc患者（n=83）和健康对照组（n=29）。同时检测CRP和ESR。结果：SSc患者的suPAR值高于对照组，而SSc患者的suPAR值高于对照组。亚组分析显示，弥漫性皮肤SSc的suPAR值高于局限性皮肤SSc，且与抗Scl-70+相关。suPAR水平还与肺功能测试参数纤维化，微血管病变的存在（例如，雷诺现象，甲襞毛细血管镜检查异常和数字溃疡）和arthritis.Conclusions：我们的数据表明，suPAR可能是一个有价值的SSc的早期诊断标志物，这也与疾病的严重程度。
Background: Urokinase plasminogen activator receptor (uPAR) is a key component of the fibrinolytic system involved in extracellular matrix remodeling and angiogenesis. Novel animal models supported the key role of uPAR not only in fibrosis but also in systemic sclerosis (SSc)-related microvascular abnormalities. The aim of this study was to investigate plasma soluble uPAR (suPAR) levels in SSc, and their association with organ-specific involvement.Methods: suPAR concentrations were measured by ELISA in SSc patient (n=83) and in healthy controls (n=29). Simultaneously, CRP and ESR were assessed. Detailed clinical data including skin, lung, heart and microvascular characteristics were evaluated at sampling.Results: suPAR values were higher in SSc patients than in controls. Subgroup analysis showed higher suPAR values in diffuse cutaneous-than in limited cutaneous SSc and correlated with anti-Scl-70+. suPAR levels also associated with pulmonary function test parameters of fibrosis, presence of microvascular lesions (e.g., Raynaud phenomenon, naifold capillaroscopic abnormalities and digital ulcers) and arthritis.Conclusions: Our data indicate that suPAR might be a valuable early diagnostic marker of SSc which also correlates with disease severity.